Serum Soluble Glycoprotein VI (sGPVI) to Predict the 28th Day In-Hospital Mortality in Adult Patients with Sepsis

Shoeib, Sabry Abd Allah; Abd ElHalim, Ayman Fathy; Abd ElHafez, Mohamad Ahmad; Dawod, Ashraf Abd ElRaof; Abd ElMohsen, Essam Ali; ElBaz, Sameh Abo ElNasr Abd ElSalam

doi:10.21608/ejhm.2020.98915

Serum Soluble Glycoprotein VI (sGPVI) to Predict the 28th Day In-Hospital Mortality in Adult Patients with Sepsis

Document Type : Original Article

Authors

10.21608/ejhm.2020.98915

Abstract

Background: Sepsis is a complicated syndrome resulting from the inappropriate expression of host factors in response to infection and is a major cause of death in patients that are hospitalized in emergency departments and in critical care units.
Objective: The purpose of the present study was to identify the role of serum soluble glycoprotein VI (sGPVI) in predicting the 28th day in-hospital mortality in adult patients with sepsis.
Patients and methods: This observational prospective cohort study included a total of 90 adult patients aged ≥18 years old with clinically suspected sepsis, recruited from Medical Intensive Care Units of Menoufia University Hospital and Kafr El-Sheikh general hospital. The included subjects were diagnosed using quick SOFA score and according to survival at the 28th day, they were divided into two groups; Group A (survivors) consisted of 69 patients (76.7%) and Group B (non survivors) consisted of 21 patients (23.3%).
Results: As regard clinico-laboratory data (qSOFA, sGPVI, SGOT, respiratory rate, ESR, WBCs) and complications (hospital stay), they are significantly increased (P value < 0.001) in non-survivor studied patients in comparison with survivor ones. Concerning platelet count, it is significantly reduced (P value < 0.001) in non-survivor studied patients in comparison with survivor ones. As regard clinico-laboratory data (qSOFA, SGOT, respiratory rate, ESR and WBCs) and complications (hospital stay), they are positively correlated with sGPVI with a statistically significant difference in non-survivor studied patients. Concerning platelet count, it is negatively correlated with sGPVI with a statistically significant difference in non-survivor studied patients.
Conclusion: It could be concluded that glycoprotein VI is a valuable prognostic predictor during sepsis being more reliable than other widely used indicators and severity scores, such as qSOFA, WBCs, platelet count and CRP.

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