Evaluation of the Most Common Complications of Sickle Cell Anemia and Management in Children: Simple Literature Review

Shuruq Hassan Alsulami4, Manal Nasser Alotaibi4, Eyman Abdulmajeed Alfaraj5,, Ghadeer Awad Alenazy1, Asma Mutni Almutairi2, Lamia Aiad Al-Onazi2, Ghaid Mohammed H Alkharaz3,; Ammar Mohammad M Bahati7, Afnan Hussain Alshaikhali5, Mahabbat Nadin Anam A6,

doi:10.21608/ejhm.2018.9076

Evaluation of the Most Common Complications of Sickle Cell Anemia and Management in Children: Simple Literature Review

Document Type : Original Article

Authors

Ghadeer Awad Alenazy1, Asma Mutni Almutairi2, Lamia Aiad Al-Onazi2, Ghaid Mohammed H Alkharaz3, Shuruq Hassan Alsulami4, Manal Nasser Alotaibi4, Eyman Abdulmajeed Alfaraj5, ¹
Afnan Hussain Alshaikhali5, Mahabbat Nadin Anam A6, Ammar Mohammad M Bahati7 ²

¹ 1- Hail University, 2- Qassim University, 3- Unaizah College of Medicine, 4- Ibn Sina Medical College, 5- Imam Abdulrahman University,

² 6- King Saud bin Abdulaziz University for Health Sciences, 7- Umm Al-Qura University

10.21608/ejhm.2018.9076

Abstract

Background: Sickle cell anemia is an autosomal structural defect that affect the hemoglobin. It is associated with reduction in the RBC life span especially under stress. As a result of this structural defect the RBCs takes a sickle shape which is associated with a lot of complications that significantly have an effect on the patient’s life. Objective: In this study, we aim at evaluating the most common complication of sickle cell anemia. Also, the assessment of the various management plans to prevent it if occurred. Methods: PubMed database were used for articles selection as well as all relevant articles to our research interest with the following topics: Sickle cell anemia, Complications, Mortality, Prevention and Management. We excluded other articles, which are not related to this field. The data were extracted according to specific form in which it is going to be reviewed by the group members. Conclusion: Sickle cell anemia have various complications that have impact on quality of life and arise from effect of three main pathophysiological mechanisms i.e. Vasooclussive, hyper-haemolytic and infective complications. Hydroxyurea, chronic blood transfusion, and routine Transcranial Doppler Ultrasound are still the most useful preventive measures of SCA complications.

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