Pharmacogenetics of Proton Pump Inhibitors: Short Review

Noshily Mohammed Abdullah A 4, Alrayani Abdullah Abdu 5, Sarhan Yasir Eisi 6,, Madkoor Mujeeb Alrhman Idaros A 1, Harshan Fahad Mohammed 2, Harisi Abdulrahman Hassan3,; Ayyashi Mohammed Ali Hussain 8, Halawi Hatim Ali A 1, Shammakhi Ibrahim Nasser M 7,

Pharmacogenetics of Proton Pump Inhibitors: Short Review

Document Type : Original Article

Authors

Madkoor Mujeeb Alrhman Idaros A 1, Harshan Fahad Mohammed 2, Harisi Abdulrahman Hassan3, Noshily Mohammed Abdullah A 4, Alrayani Abdullah Abdu 5, Sarhan Yasir Eisi 6, ¹
Halawi Hatim Ali A 1, Shammakhi Ibrahim Nasser M 7, Ayyashi Mohammed Ali Hussain 8 ²

¹ 1. King Fahad Central Hospital, 2. King Abdulaziz Special Hospital, 3.Al Hada Armed Forces Hospital, 4. Haql General Hospital, 5. Abbott Laboratories,

² 6.Sandoz Company, 7. Jazan Unversity Hospital, 8. Armed Forces Hospital Jazan

Abstract

Background: Proton pump inhibitors are substituted benzimidazoles compounds, they are used as agents for the treatment of acid-peptic diseases. These compounds are metabolized by several enzymes, the genetic variations in these enzymes were thought to influence the pharmacogenetics of the proton pump inhibitors and in turn influence the outcome of the patients.
Aim: To highlight the pharmaco-genetics of proton pump inhibitors
Methods: Scientific websites were used to search for articles such as Pubmed and Google Scholar. Several keywords were used to obtain all possible articles concerned with the subject.
Results: We reviewed 6 articles about the current subject, there were few articles about the pharmacology of proton pump inhibitors.
Conclusion: Few studies have focused on the pharmacogenetics of proton pump inhibitors and most of them were trials, also there were no previous review articles studied this subject.

Keywords