El-Messallamy, F., Soliman, J., Shalaby, S., Abdel-Rahman, H. (2020). Fetuin-A as a Marker of Insulin Resistance in Type 2 Diabetic Patients in Zagazig University. The Egyptian Journal of Hospital Medicine, 79(1), 462-468. doi: 10.21608/ejhm.2020.81284
Fawzy Abdelfatah El-Messallamy; Jehan Saeed Abdo Soliman; Sally Mahmoud Saeed Shalaby; Heba Abdel-Rahman Kamel Abdel-Rahman. "Fetuin-A as a Marker of Insulin Resistance in Type 2 Diabetic Patients in Zagazig University". The Egyptian Journal of Hospital Medicine, 79, 1, 2020, 462-468. doi: 10.21608/ejhm.2020.81284
El-Messallamy, F., Soliman, J., Shalaby, S., Abdel-Rahman, H. (2020). 'Fetuin-A as a Marker of Insulin Resistance in Type 2 Diabetic Patients in Zagazig University', The Egyptian Journal of Hospital Medicine, 79(1), pp. 462-468. doi: 10.21608/ejhm.2020.81284
El-Messallamy, F., Soliman, J., Shalaby, S., Abdel-Rahman, H. Fetuin-A as a Marker of Insulin Resistance in Type 2 Diabetic Patients in Zagazig University. The Egyptian Journal of Hospital Medicine, 2020; 79(1): 462-468. doi: 10.21608/ejhm.2020.81284
Fetuin-A as a Marker of Insulin Resistance in Type 2 Diabetic Patients in Zagazig University
1Department of Internal Medicine, Faculty of Medicine, Zagazig University, Sharkia
2Department of Biochemistry, Faculty of Medicine, Zagazig University, Sharkia
3Department of Internal Medicine, Faculty of Medicine, Banha University, Qaluobya, Egypt
Abstract
Background: Fetuin-A is responsible for instigating insulin resistance by inhibiting tyrosine kinase receptors. Objective: To investigate the relationship of fetuin-A with and insulin resistance in type- II diabetics either obese or non-obese of Zagazig University, Shatkia Governorate, Egypt. Patients and Methods: This is a case-control study that was conducted at the Internal Medicine Department of Zagazig University. Seventy-five participants were divided into three groups. Group-A (n =25) normal healthy individual, Group-B (n =25) non-obese type 2 diabetic patients and Group C (n=25) obese type 2 diabetic patients. Type 2 diabetic patients with no morbidities. Serum fetuin-A and insulin levels were performed by ELISA kits while fasting blood glucose (FBG), 2HPP and HA1C were determined by the enzymatic kit method. A comparison of groups was done and correlation was achieved by using Spearman correlation. Results: The results demonstrated a significant difference in mean values of fetuin-A, BMI, WHR, fasting blood glucose (FBG), 2HPP, HA1C, insulin level and Homoeostasis Model Assessment of Insulin resistance (HOMAIR) in type-II diabetics when compared to normal healthy individuals and obese type-II diabetics (p<0.01). The fetuin-A level was higher in obese more than non-obese type II diabetics. Conclusion: The study concluded that fetuin-A might be accountable for insulin resistance in type-II diabetes mellitus either obese or non-obese. So the high levels of Fetuin-A responsible for insulin resistance.
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