Recent Advances and Surgical Applications of Monoclonal Antibodies

Document Type : Original Article

Authors

Department of General Surgery, Faculty of Medicine, Al-Azhar University, Cairo, Egypt

Abstract

Background: Monoclonal antibodies plays an important role in surgical disease practice specially cancers, Crohn's Disease and ulcerative colitits. Monoclonal antibodies is a type of biological therapy that utilizes a person’s natural immune defense system to fight diseases. Monoclonal antibodies for cancers is essentially the stimulation of immune system via a variety of reagents such as vaccines infusion of T cells or cytokines. These reagents reacted through one of several mechanisms: 1- By stimulating the antitumor response either by increasing the number of effector cells or be production one or more soluble mediators such as lymphokines. 2- By decreasing suppressors mechanisms. 3- By altering tumor cells to increase their immunogenicity and make them more susceptible to immunological defenses. 4- By improving tolerance to cytotoxic drugs or radiotherapy such as stimulating bone marrow function with granulocyte colony stimulating factor (G- CSF). Monoclonal antibodies is a type of immunotherapy but there is another types of immunotherapy such as nonspecific immunotherapies and cancer vaccines mechanism of monoclonal antibodies in surgical disease. Objective: This work was aimed to study the role of monoclonal antibodies in surgical disease as a new tool to surgical armamentarium. Conclusion: It could be concluded from this study that monoclonal antibodies helps the body to fight disease and infection. Monoclonal antibodies are used to treat many types of carcinoma and cancers.

Keywords

The Egyptian Journal of Hospital Medicine
Volume 77, Issue 5
October 2019
Pages 5668-5676

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