Helal, E., Abdelaziz, M., Fadel, H., Zakaria, A. (2019). Study of The Effect of Bisphenol A and Anise Oil on Some Sexual Hormones in Male Albino Rats and Illustration of The Effects of Aphanizomenon Flos-Aquae on Their Actions. The Egyptian Journal of Hospital Medicine, 77(3), 5191-5198. doi: 10.21608/ejhm.2019.54173
Eman G.E. Helal; Mohamed A. Abdelaziz; Hewaida A.E. Fadel; Abeer Zakaria. "Study of The Effect of Bisphenol A and Anise Oil on Some Sexual Hormones in Male Albino Rats and Illustration of The Effects of Aphanizomenon Flos-Aquae on Their Actions". The Egyptian Journal of Hospital Medicine, 77, 3, 2019, 5191-5198. doi: 10.21608/ejhm.2019.54173
Helal, E., Abdelaziz, M., Fadel, H., Zakaria, A. (2019). 'Study of The Effect of Bisphenol A and Anise Oil on Some Sexual Hormones in Male Albino Rats and Illustration of The Effects of Aphanizomenon Flos-Aquae on Their Actions', The Egyptian Journal of Hospital Medicine, 77(3), pp. 5191-5198. doi: 10.21608/ejhm.2019.54173
Helal, E., Abdelaziz, M., Fadel, H., Zakaria, A. Study of The Effect of Bisphenol A and Anise Oil on Some Sexual Hormones in Male Albino Rats and Illustration of The Effects of Aphanizomenon Flos-Aquae on Their Actions. The Egyptian Journal of Hospital Medicine, 2019; 77(3): 5191-5198. doi: 10.21608/ejhm.2019.54173
Study of The Effect of Bisphenol A and Anise Oil on Some Sexual Hormones in Male Albino Rats and Illustration of The Effects of Aphanizomenon Flos-Aquae on Their Actions
1Zoology Department, Faculty of Science (Girls), Al-Azhar University
2Physiology Department, Faculty of Medicine, Al-Azhar university
3Department of Nutritional Chemistry& Metabolism, National Nutrition Institute, Cairo, Egypt
Abstract
Background: Xenoestrogens are compounds like estrogens in effect but not in structure which are mimicking the action of endogenous estrogen and activate estrogen receptor. Phytoestrogens are naturally occurring non-steroidal plant chemicals that can act like the female hormone estrogen. Aphanizomenon Flos-aquae (AFA) is a blue-green microalgal species which has antioxidant properties. Objective: The aim of the study was to clarify the effects of both Bisphenol A (BPA) and anise oil (phytoestrogen) together on some sexual hormonal pattern in male albino rats and illustration of the adverse effects of AFA on their actions. Materials and methods: Thirty male albino rats were used. They were divided into three groups: Group I: control (untreated group), Group II: rats treated with BPA and Anise oil and Group III: rats treated with BPA and Anise oil in addition to AFA. Blood samples were collected for different biochemical investigations. Results: The biochemical results showed highly significant increase (p<0.01) in the activities of ALT, AST, urea, creatinine, FSH, prolactin and lipid profile (total cholesterol, triglycerides, HDL-C, VLDL, LDL/HDL & TC/HDL). While, there was a highly significant decrease (p < 0.01) in LDL-C, total protein, albumin, Globulin, testosterone and LH. These results returned back to the normal values after receiving the AFA as compared to normal group. Conclusion: It could be concluded that phytoestrogen and xenoestrogen have undesirable effects and it is recommended to minimize the utilization of these compounds to protect people from its hazardous effects.
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