Abd-Elfattah, A., Elomda, F., Hashish, M., Megahed, H. (2019). Effect of Adding L-Carnitine to Clomiphene Resistant PCOs Women on the Ovulation and the Pregnancy Rate. The Egyptian Journal of Hospital Medicine, 76(5), 4138-4143. doi: 10.21608/ejhm.2019.43079
Ahmed Taha Abd-Elfattah; Fahd Abd El-aal Elomda; Mahmoud Abd-Ellatif Hashish; Hossam Ibrahim Megahed. "Effect of Adding L-Carnitine to Clomiphene Resistant PCOs Women on the Ovulation and the Pregnancy Rate". The Egyptian Journal of Hospital Medicine, 76, 5, 2019, 4138-4143. doi: 10.21608/ejhm.2019.43079
Abd-Elfattah, A., Elomda, F., Hashish, M., Megahed, H. (2019). 'Effect of Adding L-Carnitine to Clomiphene Resistant PCOs Women on the Ovulation and the Pregnancy Rate', The Egyptian Journal of Hospital Medicine, 76(5), pp. 4138-4143. doi: 10.21608/ejhm.2019.43079
Abd-Elfattah, A., Elomda, F., Hashish, M., Megahed, H. Effect of Adding L-Carnitine to Clomiphene Resistant PCOs Women on the Ovulation and the Pregnancy Rate. The Egyptian Journal of Hospital Medicine, 2019; 76(5): 4138-4143. doi: 10.21608/ejhm.2019.43079
Effect of Adding L-Carnitine to Clomiphene Resistant PCOs Women on the Ovulation and the Pregnancy Rate
1Departments of Obstetrics & Gynecology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt
2Departments of Clinical Pathology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt
Abstract
Background: polycystic ovary (PCO) syndrome is an endocrionologic disorder that affecting about 6-10% of women in their reproductive age. Conception rate with clomiphene citrate treated cycles is about 40% only and the number of ovulated oocyte decrease significantly with repeated cycles of ovulation. Objective: evaluation of the effectiveness of usage of clomiphene citrate with L-carnitine (LC) in induction of ovulation in clomiphene citrate resistant patients. Patients and Methods: Randomized controlled study included a total number of 50 women with clomiphene-resistant PCOs. They were divided into 2 groups, group (A) where patients received 100 to 150 mg clomiphene citrate from day three until day seven of the cycle and L-carnitine (LC) 3g daily till positive pregnancy test and group (B) received 100 to 150 mg clomiphene citrate with placebo. Results: There was statistically significant difference (p-value <0.05) between both groups as regard infertility duration (months), ovulation rate, no. of chemical pregnancies and no. of clinical pregnancies. There was highly statistically significant difference (p-value < 0.001) between both groups as regard days until HCG injection, endometrial thickness (mm), no. of pre-ovulatory follicles >17 mm and E2 on day of HCG injection. Conclusion: Adding L-carnitine to clomiphene from the follicular phase and extending through the luteal phase in patients with clomiphene-resistant PCOS, at the given dose and duration, may be of beneficial to the quality of ovulation and the clinical pregnancy rate.
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