Badr El Dien, H., Abd Elwahab, A., Abdalla, E. (2019). The Efficacy of Serum Biomarkers and Ultrasound Parameters in Prediction of Outcome in Threatened Abortion. The Egyptian Journal of Hospital Medicine, 76(4), 3835-3839. doi: 10.21608/ejhm.2019.41523
Hanaa Omer Badr El Dien; Asmaa Mahmoud Abd Elwahab; Eman Mostafa Abdalla. "The Efficacy of Serum Biomarkers and Ultrasound Parameters in Prediction of Outcome in Threatened Abortion". The Egyptian Journal of Hospital Medicine, 76, 4, 2019, 3835-3839. doi: 10.21608/ejhm.2019.41523
Badr El Dien, H., Abd Elwahab, A., Abdalla, E. (2019). 'The Efficacy of Serum Biomarkers and Ultrasound Parameters in Prediction of Outcome in Threatened Abortion', The Egyptian Journal of Hospital Medicine, 76(4), pp. 3835-3839. doi: 10.21608/ejhm.2019.41523
Badr El Dien, H., Abd Elwahab, A., Abdalla, E. The Efficacy of Serum Biomarkers and Ultrasound Parameters in Prediction of Outcome in Threatened Abortion. The Egyptian Journal of Hospital Medicine, 2019; 76(4): 3835-3839. doi: 10.21608/ejhm.2019.41523
The Efficacy of Serum Biomarkers and Ultrasound Parameters in Prediction of Outcome in Threatened Abortion
Department of Obstetrics and Gynecology, of Medicine, Al-Azhar University
Abstract
Background: miscarriage, also known as a spontaneous loss of pregnancy before the fetus reaches viability. Objectives: the aim of this study is to evaluate the association between ultrasonographic findings and maternal serum biomarkers levels and prediction of pregnancy outcome in threatened miscarriage. Patients and Methods: a prospective observational study was conducted at Al-Zahraa University Hospital through the period from April 2018 to May 2019 involving 76 women in their first trimester threatened abortion. Results: there was a statistically significant difference between group 1 and group 2 regarding cancer antigen (CA) 125, β-hCG, progesterone, yolk sac diameter (YSD), fetal heart rate (FHR) and crown-rump length (CRL). The sensitivity, specificity, PPV and NPV of CA 125 at 37.2 IU/ml were 86.0, 84.3, 84.6 and 85.7, respectively, for β-hCG at 19447 IU/ml were 80.6, 78.0, 78.4 and 79.8, respectively, for progesterone at 12.3 ng/ml were 90.1, 88.0, 88.2 and 89.8, respectively, and for FHR at 122 b pm were 96.1, 94.1 respectively. Conclusion: combining of measurement of serum progesterone at a level of 12.3 ng/ml to FHR at 122 bpm represent noninvasive, early, fast and excellent predictor of pregnancy outcome in women with threatened abortion.
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