El Ghannam, M., Ali, A., El Samanoudy, M., Kamel, A. (2019). Assessment of The Level of Protein C in Children with Nephrotic Syndrome. The Egyptian Journal of Hospital Medicine, 76(3), 3828-3834. doi: 10.21608/ejhm.2019.41345
Magdy Zaky El Ghannam; Ahmed Abd El Moez Ali; Mohamed Ibrahim El Samanoudy; Ayman Ramadan Kamel. "Assessment of The Level of Protein C in Children with Nephrotic Syndrome". The Egyptian Journal of Hospital Medicine, 76, 3, 2019, 3828-3834. doi: 10.21608/ejhm.2019.41345
El Ghannam, M., Ali, A., El Samanoudy, M., Kamel, A. (2019). 'Assessment of The Level of Protein C in Children with Nephrotic Syndrome', The Egyptian Journal of Hospital Medicine, 76(3), pp. 3828-3834. doi: 10.21608/ejhm.2019.41345
El Ghannam, M., Ali, A., El Samanoudy, M., Kamel, A. Assessment of The Level of Protein C in Children with Nephrotic Syndrome. The Egyptian Journal of Hospital Medicine, 2019; 76(3): 3828-3834. doi: 10.21608/ejhm.2019.41345
Assessment of The Level of Protein C in Children with Nephrotic Syndrome
1Department of Clinical Pathology, Faculty of Medicine, Al-Azhar University
2Departments of Pediatric and Neonates, Faculty of Medicine, Al-Azhar University
Abstract
Background: thromboembolic events remain one of the most serious complications in patients with nephrotic syndrome and this thrombotic tendency could be related to deficiency in natural coagulation inhibitors. Objective: the aim of our study was to estimate P-C quantity &quality in the blood of nephrotic patients for the possible role that it might play in the pathogenesis of thromboembolic complications in these patients & trial to find correlations between P-C & some hemostatic parameters. Patient and Methods: this study was carried out on 60 children (age: 3-13years) were diagnosed as nephrotic patients. They were classified as follow: G1- comprised of 20 cases in relapse, G2- comprised of 20 cases in remission (the same cases of relapse), G3- comprised of 20 healthy children as control group. Results: Our study showed very high significant increase in P-C, both in activity and concentration in relapse but in remission its level decreased towards the normal level but still slightly increased and this increase is statistically nonsignificant. As regard serum albumin and serum total protein, the both were very highly significantly increased in relapse and remission as compared to the control. As regard PT and PTT were found to be highly significant decreased in relapse as compared to the control group. Conclusion: from the foregoing we can concluded that, Increase level of P-C in N.S. denoted that it has no role in thromboembolic complications and Increase level of P-C in N.S may afford some protection against the thrombotic diathesis by counteracting hypercoagulability state.
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