Effects Of CANDEREL® and The Ameliorative Role of Stem Cell Enhancer on Some Physiological Parameters in Male Albino Rats

Document Type : Original Article

Authors

1 Department of Zoology, Faculty of Science (Girls), Al-Azhar University

2 Medical Physiology, Faculty of Medicine, Al-Azhar University

Abstract

Background: CANDEREL® is non-nutritive artificial sweetener, which is mainly composed of aspartame and acesulfame potassium. Materials and Methods: thirty male albino rats weighing from 100 to 120 gm. The period of the experiment was 30 days. The animals were divided into three groups; group 1: control, group 2: rats received CANDEREL® (1 tablet/25kg b.w./day) and group 3: rats received CANDEREL® (1 tablet/25kg b.w./day) + SCE (9 mg/kg b.w./day). The following parameters were measured: serum glucose, ASAT, ALAT, serum creatinine, serum urea, protein and lipid profiles and hormonal levels (insulin, testosterone, serum T3 and serum T4). Results: there were many disturbances that occurred in the previous parameters, and SCE ameliorated most of these hazardous effects. Conclusion: artificial sweeteners are not safe in use; their disadvantages are more than their advantages. So, we recommended replacing non-nutritive sweeteners with nutritive ones to be away from any hazardous effects that may result from the use of artificial sweeteners. Also, SCE made a great job in fighting the impairments that occur during the experiment.

Keywords

The Egyptian Journal of Hospital Medicine
Volume 76, Issue 3
July 2019
Pages 3702-3708

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