Saleh, S., Algharabawy, G., Hablas, M. (2019). Comparative Histological and Immunohistochemical Study on The Effect of Curcumin and Atorvastatin in Induced Atherosclerosis in Aorta and Cardiac Muscle of Male Rabbits. The Egyptian Journal of Hospital Medicine, 76(2), 3500-3515. doi: 10.21608/ejhm.2019.38653
Sheriff Aly Saleh; Gamal Soliman Algharabawy; Mohamed Ghazy Attia Hablas. "Comparative Histological and Immunohistochemical Study on The Effect of Curcumin and Atorvastatin in Induced Atherosclerosis in Aorta and Cardiac Muscle of Male Rabbits". The Egyptian Journal of Hospital Medicine, 76, 2, 2019, 3500-3515. doi: 10.21608/ejhm.2019.38653
Saleh, S., Algharabawy, G., Hablas, M. (2019). 'Comparative Histological and Immunohistochemical Study on The Effect of Curcumin and Atorvastatin in Induced Atherosclerosis in Aorta and Cardiac Muscle of Male Rabbits', The Egyptian Journal of Hospital Medicine, 76(2), pp. 3500-3515. doi: 10.21608/ejhm.2019.38653
Saleh, S., Algharabawy, G., Hablas, M. Comparative Histological and Immunohistochemical Study on The Effect of Curcumin and Atorvastatin in Induced Atherosclerosis in Aorta and Cardiac Muscle of Male Rabbits. The Egyptian Journal of Hospital Medicine, 2019; 76(2): 3500-3515. doi: 10.21608/ejhm.2019.38653
Comparative Histological and Immunohistochemical Study on The Effect of Curcumin and Atorvastatin in Induced Atherosclerosis in Aorta and Cardiac Muscle of Male Rabbits
1Department of Histology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt
2Department of Histology, Faculty of Medicine, Al-Azhar University, Assiut, Egypt
Abstract
Background: curcumin has many pharmacological effects including antioxidant, anti-inflammation, eliminating free radicals, anti-tumor, lipid regulation and anti-coagulation. Objectives: to compare the histological effects of curcumin and atorvastatin in experimental induced atherosclerosis in the rabbit’s aorta and heart. Subjects and Methodology: thoracic aorta sections were prepared and stained by Hx&E, orcein, Masson's trichrome and immuonohistochemical staning using CD34. Cardiac sections were prepared and stained by Hx&E, Masson's trichrome stain and immuonohistochemical staning using troponin T. Morphometrical study included, the thickness of both tunica intima and media of thoracic aorta , area % of the elastic fibers contents of both tunica intima and media in thorathic aorta, and the area %of the immune reaction of CD34 in thoracic aorta . Results: the atherosclerotic group showed a significant increase in the thickness of both tunicae intima& media when compared with the control group. There was a significant decrease in elastic fibers content and significant increase in the mean area % of the immune reaction of CD34 versus control. In atorvastatin treated group: there was a significant increase in comparison to control group, while there was a significant decrease in comparison to atherosclerotic group. There was significant decrease in elastic fibers content and significant increase in the mean area % of the immune reaction of CD34 in comparison to control group. In curcumin treated group: the thickness of both tunica intima and media showed a significant increase in comparison to control group. Conclusion: curcumin has potential role in treatment of atherosclerosis and myocardial infarction.
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