Helal, E., Fadal, H., Ikechukwu, G., Abd-El-Aziz, M., Ahmed, S. (2019). Phytoestrogens Soymilk and Fenugreek Oil Perturb Lipid and Hormonal Profile and Other Physiological Parameters of Male Albino Rats. The Egyptian Journal of Hospital Medicine, 76(2), 3494-3499. doi: 10.21608/ejhm.2019.37937
Eman G.E. Helal; Hewaida, A.E. Fadal; Gavin C. Ikechukwu; Mohamed A. Abd-El-Aziz; Shaimaa S. Ahmed. "Phytoestrogens Soymilk and Fenugreek Oil Perturb Lipid and Hormonal Profile and Other Physiological Parameters of Male Albino Rats". The Egyptian Journal of Hospital Medicine, 76, 2, 2019, 3494-3499. doi: 10.21608/ejhm.2019.37937
Helal, E., Fadal, H., Ikechukwu, G., Abd-El-Aziz, M., Ahmed, S. (2019). 'Phytoestrogens Soymilk and Fenugreek Oil Perturb Lipid and Hormonal Profile and Other Physiological Parameters of Male Albino Rats', The Egyptian Journal of Hospital Medicine, 76(2), pp. 3494-3499. doi: 10.21608/ejhm.2019.37937
Helal, E., Fadal, H., Ikechukwu, G., Abd-El-Aziz, M., Ahmed, S. Phytoestrogens Soymilk and Fenugreek Oil Perturb Lipid and Hormonal Profile and Other Physiological Parameters of Male Albino Rats. The Egyptian Journal of Hospital Medicine, 2019; 76(2): 3494-3499. doi: 10.21608/ejhm.2019.37937
Phytoestrogens Soymilk and Fenugreek Oil Perturb Lipid and Hormonal Profile and Other Physiological Parameters of Male Albino Rats
1Zoology Department, Faculty of Science, Al-Azhar University (Girls)
2Physiology and Nutritional Chemistry, National Nutrition Institute, Cairo, Egypt
3Biochemistry Department, College of Natural Sciences, Michael Okpara University of Agriculture, Umudike, Nigeria
4Physiology Department, Faculty of Medicine, Al-Azhar University (Boys), Cairo, Egypt
Abstract
Background: phytoestrogens are a diverse group of plant-derived compounds that structurally or functionally mimic mammalian estrogens. They have been investigated at the epidemiological, clinical and molecular levels to determine their potential health benefits. Aim: the present study was carried out to investigate some biochemical effects of fenugreek oil and soymilk on male albino rats. Materials and Methods: eighteen (18) animals were divided randomly into three groups with 6 animals per group. Group “1” received normal saline 1 mL/kg body weight orally for four weeks. Group “2” rats were treated with oral dose of soymilk 1 ml/kg body weight/day once daily for four weeks, while rats in group “3” were treated with oral dose of fenugreek 1 ml/kg body weight/day once daily for four weeks. Blood samples were collected on the last day of the experiment for biochemical analysis. Results: the fenugreek oil and soymilk induced highly significant decrease (p<0.01) in total cholesterol, triacylglycerol, low-density lipoprotein, very low-density lipoprotein, low-density lipoprotein high-density lipoprotein ratio (LDL/HDL) and a significant increase (p<0.05) in high-density lipoprotein. The results also showed highly significant decrease in follicle stimulating hormone, luteinizing hormone, testosterone and sperm count compared to normal control group. Conclusion: the results of this study suggest that high levels of fenugreek and soymilk intake can cause hormonal disturbance and decrease sperm count.
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