Home Articles List Article Information
The Egyptian Journal of Hospital Medicine
Journal Archive
Volume Volume 97 (2024)
Volume Volume 96 (2024)
Volume Volume 95 (2024)
Volume Volume 94 (2024)
Volume Volume 93 (2023)
Volume Volume 92 (2023)
Volume Volume 91 (2023)
Volume Volume 90 (2023)
Volume Volume 89 (2022)
Volume Volume 88 (2022)
Volume Volume 87 (2022)
Volume Volume 86 (2022)
Volume Volume 85 (2021)
Volume Volume 84 (2021)
Volume Volume 83 (2021)
Volume Volume 82 (2021)
Volume Volume 81 (2020)
Volume Volume 80 (2020)
Volume Volume 79 (2020)
Volume Volume 78 (2020)
Volume Volume 77 (2019)
Volume Volume 76 (2019)
Volume Volume 75 (2019)
Volume Volume 74 (2019)
Volume Volume 73 (2018)
Volume Volume 72 (2018)
Volume Volume 71 (2018)
Volume Volume 70 (2018)
Volume Volume 69 (2017)
Volume Volume 68 (2017)
Volume Volume 67 (2017)
Volume Volume 66 (2017)
Volume Volume 65 (2016)
Volume Volume 64 (2016)
Volume Volume 63 (2016)
Volume Volume 62 (2016)
Volume Volume 61 (2015)
Volume Volume 60 (2015)
Volume Volume 59 (2015)
Volume Volume 58 (2015)
Volume Volume 57 (2014)
Volume Volume 56 (2014)
Volume Volume 55 (2014)
Volume Volume 54 (2014)
Volume Volume 53 (2013)
Volume Volume 52 (2013)
Volume Volume 51 (2013)
Volume Volume 50 (2013)
Volume Volume 49 (2012)
Volume Volume 48 (2012)
Volume Volume 47 (2012)
Volume Volume 46 (2012)
Volume Volume 45 (2011)
Volume Volume 44 (2011)
Volume Volume 43 (2011)
Volume Volume 42 (2011)
Volume Volume 41 (2010)
Volume Volume 40 (2010)
Volume Volume 39 (2010)
Volume Volume 38 (2010)
Volume Volume 37 (2009)
Volume Volume 36 (2009)
Volume Volume 35 (2009)
Volume Volume 34 (2009)
Volume Volume 33 (2008)
Volume Volume 32 (2008)
Volume Volume 31 (2008)
Volume Volume 30 (2008)
Volume Volume 29 (2007)
Volume Volume 28 (2007)
Volume Volume 27 (2007)
Volume Volume 26 (2007)
Volume Volume 25 (2006)
Volume Volume 24 (2006)
Volume Volume 23 (2006)
Volume Volume 22 (2006)
Volume Volume 21 (2005)
Volume Volume 20 (2005)
Volume Volume 19 (2005)
Volume Volume 18 (2005)
Volume Volume 17 (2004)
Volume Volume 16 (2004)
Volume Volume 15 (2004)
Volume Volume 14 (2004)
Volume Volume 13 (2003)
Volume Volume 12 (2003)
Volume Volume 11 (2003)
Volume Volume 10 (2003)
Volume Volume 9 (2002)
Volume Volume 8 (2002)
Volume Volume 7 (2002)
Volume Volume 6 (2002)
Volume Volume 5 (2001)
Volume Volume 4 (2001)
Volume Volume 3 (2001)
Volume Volume 2 (2001)
Volume Volume 1 (2000)
Naeem, S., Sabry, H., Abduh, M., Matboly, M. (2019). Histological Study of Emerging Role of Exosomes Based Therapeutic in Management of Hepatocellular Carcinoma Rat Model. The Egyptian Journal of Hospital Medicine, 76(1), 3237-3244. doi: 10.21608/ejhm.2019.36034
Suhaib Naeem; Hassan Sabry; Mohammed Abduh; Marwa Matboly. "Histological Study of Emerging Role of Exosomes Based Therapeutic in Management of Hepatocellular Carcinoma Rat Model". The Egyptian Journal of Hospital Medicine, 76, 1, 2019, 3237-3244. doi: 10.21608/ejhm.2019.36034
Naeem, S., Sabry, H., Abduh, M., Matboly, M. (2019). 'Histological Study of Emerging Role of Exosomes Based Therapeutic in Management of Hepatocellular Carcinoma Rat Model', The Egyptian Journal of Hospital Medicine, 76(1), pp. 3237-3244. doi: 10.21608/ejhm.2019.36034
Naeem, S., Sabry, H., Abduh, M., Matboly, M. Histological Study of Emerging Role of Exosomes Based Therapeutic in Management of Hepatocellular Carcinoma Rat Model. The Egyptian Journal of Hospital Medicine, 2019; 76(1): 3237-3244. doi: 10.21608/ejhm.2019.36034

Histological Study of Emerging Role of Exosomes Based Therapeutic in Management of Hepatocellular Carcinoma Rat Model

Article 12, Volume 76, Issue 1, July 2019, Page 3237-3244  XML PDF (818.9 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2019.36034
View on SCiNiTO View on SCiNiTO
Authors
Suhaib Naeem email 1; Hassan Sabry1; Mohammed Abduh1; Marwa Matboly2
1Department of Histology and Cell Biology, Faculty of medicine, Al-Azhar University, Cairo, Egypt
2Departments of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Ain Shams University, Cairo, Egypt
Abstract
Background: hepatocellular carcinoma (HCC) is the most common type of primary liver cancers with high incidence and mortality rates. The major risk factor for HCC is cirrhosis, which occurs usually due to HBV and HCV infection. Exosomes thought that have a major role on the promotion and spread of HCC, which can be uased as therapeutic and diagnostic marker. Objectives: we aimed to use evaluate their role in HCC assessment and their use as potential selected diagnostic biomarkers, and to characterize the efficacy of Hesperidin on modulating exosomal production and exosomal non-coding RNA related HCC expression using animal models. Materials and Methods: the study included 30 Rats devised to 5 groups 6 on each, controle and DiethyleNitros amine (DEN) and Acetamidofluorene (2-AAF) to iduce HCC group and Hispiridine treated groups with three different dosos 50 mg, 100 mg and 200 mg respectively for three groups. infants with neonatal cholestasis in three groups. Results: improvement of all of them, regarding liver histopathology wich the HCC focus regressed , regarding exosomal abundance in the serumand tissues while the evaluation of exosomal RAB11A-mRNA in rats' samples was performed by real time PCR, then the results were statistically analyzed by the SPSS software. Finally regarding to liver function test which the ALT, bilirubin and AFP reduced in the treated groups. Conclusion: exosomal RAB11A-mRNA as biomarkers for HCC inducedrats and target these exosomal markers using Hesperidin in animal model and hence we can uses as thrapuetic bases in HCC in the future.
Keywords
HCC; exosomes; DEN and 2-AAF and Hispiridine
Statistics
Article View: 361
PDF Download: 435