Madkour, H., Wafa, Y., Amer, A. (2019). Effect of Vaginal Low Dose Sildenafil on the Outcome of ICSI after ICSI Failures Attributed to Poor Endometrial Development. The Egyptian Journal of Hospital Medicine, 75(2), 2272-2275. doi: 10.21608/ejhm.2019.30527
Huda T. Madkour; Yahia A. Wafa; Ahmed S. Amer. "Effect of Vaginal Low Dose Sildenafil on the Outcome of ICSI after ICSI Failures Attributed to Poor Endometrial Development". The Egyptian Journal of Hospital Medicine, 75, 2, 2019, 2272-2275. doi: 10.21608/ejhm.2019.30527
Madkour, H., Wafa, Y., Amer, A. (2019). 'Effect of Vaginal Low Dose Sildenafil on the Outcome of ICSI after ICSI Failures Attributed to Poor Endometrial Development', The Egyptian Journal of Hospital Medicine, 75(2), pp. 2272-2275. doi: 10.21608/ejhm.2019.30527
Madkour, H., Wafa, Y., Amer, A. Effect of Vaginal Low Dose Sildenafil on the Outcome of ICSI after ICSI Failures Attributed to Poor Endometrial Development. The Egyptian Journal of Hospital Medicine, 2019; 75(2): 2272-2275. doi: 10.21608/ejhm.2019.30527
Effect of Vaginal Low Dose Sildenafil on the Outcome of ICSI after ICSI Failures Attributed to Poor Endometrial Development
Department of Obstetrics and Gynecology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt
Abstract
Background: Endometrial thickness is a marker of endometrial receptivity and a prognostic factor for embryo transfers (ET). Poor endometrium is a multifactorial condition; so, its management should be cause-related. One of the treatment options is Sildenafil citrate intake. It causes uterine vascularity improvement. Objectives: The aim of the current work was to evaluate the effects of vaginally administered doses of sildenafil on endometrial lining and ICSI outcome in infertile women with poor endometrial development. Patients and Methods: This study included a total of thirty infertile women with at least one prior ICSI failure attributed to inadequate endometrial development, undergoing ICSI procedure attending at a private assisted reproductive center. All patients underwent ICSI using a long GnRH-a protocol with the addition of sildenafil vaginal suppositories (20 mg, 4 times per day) for 10 days beginning with ovulation induction and continued until trigger day. Results: The results showed that increased endometrial thickness due to treatment with sildenafil to reach 12-14 mm in 28 out of 30 cases and was associated with a pregnancy rate of 60.7% if compared to the same group thickness. Also, another effect of sildenafil citrate was increasing the endometrial trilaminar pattern in 27 case and subsequently with high pregnancy rate. Conclusion: Increased endometrial thickness due to sildenafil therapy was associated with high pregnancy rat and its intake was associated with increased trilaminar endometrial pattern in 90% of patients which causes high pregnancy rate.
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