Maarouf, M., Hussein, M., El Sayed, R. (2023). Effect of Aminophylline on Incidence of Apnea and Recovery Time during Propofol Sedation for Gastrointestinal Endoscopy. The Egyptian Journal of Hospital Medicine, 91(1), 3896-3901. doi: 10.21608/ejhm.2023.293480
Mohammed M. Maarouf; Mostafa M. Hussein; Rania G. El Sayed. "Effect of Aminophylline on Incidence of Apnea and Recovery Time during Propofol Sedation for Gastrointestinal Endoscopy". The Egyptian Journal of Hospital Medicine, 91, 1, 2023, 3896-3901. doi: 10.21608/ejhm.2023.293480
Maarouf, M., Hussein, M., El Sayed, R. (2023). 'Effect of Aminophylline on Incidence of Apnea and Recovery Time during Propofol Sedation for Gastrointestinal Endoscopy', The Egyptian Journal of Hospital Medicine, 91(1), pp. 3896-3901. doi: 10.21608/ejhm.2023.293480
Maarouf, M., Hussein, M., El Sayed, R. Effect of Aminophylline on Incidence of Apnea and Recovery Time during Propofol Sedation for Gastrointestinal Endoscopy. The Egyptian Journal of Hospital Medicine, 2023; 91(1): 3896-3901. doi: 10.21608/ejhm.2023.293480
Effect of Aminophylline on Incidence of Apnea and Recovery Time during Propofol Sedation for Gastrointestinal Endoscopy
Background: Apnea may occur during propofol sedation for endoscopy, which can be harmful to the patient and disruptive to the procedure. Objective: To test the hypothesis that a small dose of aminophylline before propofol sedation may result in a lower incidence of apnea, as well as faster emergence from sedation. Patients and Methods: The researchers conducted a single-center, prospective randomized controlled study on 76 adult ASA I or II patients with age ranged from 20 to 65 years old. They were admitted for upper gastrointestinal or colonoscopic endoscopies. All patients were sedated with 25µg fentanyl, 1mg/kg propofol bolus over 30 seconds, then propofol boluses (0.5 mg/kg) according to need. Patients were divided into two groups: Control group [Group C (n=38)], and a study group [Group Am (n=38)] who received 0.5 mg/kg aminophylline preoperatively. Apneas were counted during each procedure, and emergence from sedation was assessed with modified Aldrete score. Results: There was a statistically significant decrease in the overall incidence of apneas with aminophylline premedication (P = 0.025), as well as a reduction in the number of apneas per bolus of propofol (P = 0.006). However, there was no statistically significant difference regarding the average time to modified Aldrete score both when tested after 5 minutes or after 10 minutes after discharge from the endoscopy room. Conclusion: Premedication with a small dose of intravenous aminophylline significantly reduces the incidence of apnea during propofol sedation for gastrointestinal endoscopies, while its effect on emergence from sedation is not significant.
View on SCiNiTO
Top