Morshedy, N., Badr Eldein, A., Hassan, M., Teama, M. (2023). The Pattern of Cardiovascular Manifestations in Egyptian Patients With Ankylosing Spondylitis and Its Relation to Disease Activity. The Egyptian Journal of Hospital Medicine, 90(1), 37-46. doi: 10.21608/ejhm.2023.279184
Nashwa Aly Morshedy; Amina Badr Eldein; Mostafa Kamel Hassan; Mohammed Abd El Monem Teama. "The Pattern of Cardiovascular Manifestations in Egyptian Patients With Ankylosing Spondylitis and Its Relation to Disease Activity". The Egyptian Journal of Hospital Medicine, 90, 1, 2023, 37-46. doi: 10.21608/ejhm.2023.279184
Morshedy, N., Badr Eldein, A., Hassan, M., Teama, M. (2023). 'The Pattern of Cardiovascular Manifestations in Egyptian Patients With Ankylosing Spondylitis and Its Relation to Disease Activity', The Egyptian Journal of Hospital Medicine, 90(1), pp. 37-46. doi: 10.21608/ejhm.2023.279184
Morshedy, N., Badr Eldein, A., Hassan, M., Teama, M. The Pattern of Cardiovascular Manifestations in Egyptian Patients With Ankylosing Spondylitis and Its Relation to Disease Activity. The Egyptian Journal of Hospital Medicine, 2023; 90(1): 37-46. doi: 10.21608/ejhm.2023.279184
The Pattern of Cardiovascular Manifestations in Egyptian Patients With Ankylosing Spondylitis and Its Relation to Disease Activity
Department of Internal Medicine, Rheumatology and Immunology, Faculty of Medicine, Ain Shams University, Egypt
Abstract
Background: Cardiovascular manifestations are one of the most common extraarticular features of ankylosing spondylitis (AS) patients. Objective: To characterize the cardiovascular symptoms of AS in a sample of Egyptian patients and to establish a connection between these symptoms and disease activity. Patients and Methods: Forty adults with Spondyloarthritis (SpA) were chosen at random from Ain Shams University Hospital and diagnosed using Assessment of Spondyloarthritis International Society (ASAS) criteria for current cross-sectional study. All patients underwent detailed history taking, full clinical examination, laboratory investigations including (CBC, ESR, CRP, lipid profile) resting electrocardiogram, cardiac echo and carotid duplex to measure Carotid Intima-Media Thickness (CIMT), and evaluate disease activity using the Ankylosing Spondylitis Disease Activity Score (ASDAS)-C-reactive protein. Results: The majority of patients (about 66%) experienced cardiac symptoms have had a valvular lesion, with tricuspid regurgitation being the most common symptom (42.5%) then diastolic dysfunction (25%) followed by systolic dysfunction (20%), intra cardiac mass (5%) and pericardial effusion (2.5%). Most of our patients had abnormal lipid profile (hypertriglycerdemia 87.5%, hyperchlostremia in 80%, high LDL in 90%), 21 patients (52.5%) had abnormal CIMT. The ASDAS-CRP score of the patients was ranged from 0.4-4.6. It was statistically significant correlated with age, multiple cardiovascular lesions as systolic dysfunction, diastolic dysfunction (p < 0.05), different forms arrhythmias, and CIMT (p < 0.05) although there is no statistically significant link to lipid profile (p>0.05). Conclusion: Cardiovascular affection in AS patients is frequent, whether being clinical or subclinical and it is related in a way to high disease activity.
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