Asfour, A., Afia, A., El-Shorbgy, M., Mohamed, M. (2019). Study of Serum Leptin in Polytransfused Children with Beta Thalassemia Major. The Egyptian Journal of Hospital Medicine, 74(5), 1137-1150. doi: 10.21608/ejhm.2019.26380
Ahmed Mohamed Abd EL-Gawad Asfour; Ali Abd El-Latif Afia; Mohamed Saeed El-Shorbgy; Mohamed Abd El-kareim Mohamed. "Study of Serum Leptin in Polytransfused Children with Beta Thalassemia Major". The Egyptian Journal of Hospital Medicine, 74, 5, 2019, 1137-1150. doi: 10.21608/ejhm.2019.26380
Asfour, A., Afia, A., El-Shorbgy, M., Mohamed, M. (2019). 'Study of Serum Leptin in Polytransfused Children with Beta Thalassemia Major', The Egyptian Journal of Hospital Medicine, 74(5), pp. 1137-1150. doi: 10.21608/ejhm.2019.26380
Asfour, A., Afia, A., El-Shorbgy, M., Mohamed, M. Study of Serum Leptin in Polytransfused Children with Beta Thalassemia Major. The Egyptian Journal of Hospital Medicine, 2019; 74(5): 1137-1150. doi: 10.21608/ejhm.2019.26380
Study of Serum Leptin in Polytransfused Children with Beta Thalassemia Major
1Pediatric Department, Faculty of Medicine Al-Azhar University
2Clinical pathology Department, Faculty of Medicine Al-Azhar University
Abstract
Background: thalassemic patients with frequent blood transfusion can result in iron overload and increase serum ferritine level. Leptin is a polypeptide hormone that is mainly expressed in bone marrow and adipocytes and previous studies consumed that it is lower in thalassemic patients compared to healthy children as a result of hemsedrosis. Objectives: The aim of this study was to evaluate leptin serum levels in patients with β- thalassemia major. Patients and methods:This case-control study was conducted on 50 children from 13 to 17 years old, at Al-Azhar university Hospitals (Sayed Galal & Al-Hussien hospitals). They were subdivided in two groups 30 patients (ß- thalassemia major) and 20 as control that were matched in age and sex. All Children were examined to be free from heart disease , iron deficiency anemia, kidney disease, diabetes, fever and systemic diseases were enrolled after taking informed consent of their parents. After collecting the samples, leptin and ferritin levels of the serum were measured in two groups by ELISA method. Then, the data were analyzed by the related statistical tests and SPSS 20 software. Results: The mean of the serum levels of leptin and ferritin showed a significant difference in the case and control groups (P-value < 0.05). Levels of leptin in the case group showed no significant gender difference (P-value < 0.05). Conclusion: Based on the results of this study, thalassemia major reduces serum levels of leptin regardless of age and body mass.
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