Fathi, M., Ali, A., Mohammed, A. (2021). Efficacy of Lactoferrin in Prevention of Premature Rupture of Membrane. The Egyptian Journal of Hospital Medicine, 85(1), 2823-2827. doi: 10.21608/ejhm.2021.190182
Manar Abdelhafeez Fathi; Ali El-Shabrawy Ali; Ahmed Ismail Mohammed. "Efficacy of Lactoferrin in Prevention of Premature Rupture of Membrane". The Egyptian Journal of Hospital Medicine, 85, 1, 2021, 2823-2827. doi: 10.21608/ejhm.2021.190182
Fathi, M., Ali, A., Mohammed, A. (2021). 'Efficacy of Lactoferrin in Prevention of Premature Rupture of Membrane', The Egyptian Journal of Hospital Medicine, 85(1), pp. 2823-2827. doi: 10.21608/ejhm.2021.190182
Fathi, M., Ali, A., Mohammed, A. Efficacy of Lactoferrin in Prevention of Premature Rupture of Membrane. The Egyptian Journal of Hospital Medicine, 2021; 85(1): 2823-2827. doi: 10.21608/ejhm.2021.190182
Efficacy of Lactoferrin in Prevention of Premature Rupture of Membrane
1Department of Obstetrics and Gynecology, Faculty of Medicine, Zagazig University, Egypt
2Department of Obstetrics and Gynecology, Faculty of Medicine, Zagazig University, Egypt.
Abstract
Background: Prematurity is a leading cause of maternal and neonatal mortality and morbidity, complicating up to 10% of all pregnancies. Mortality and morbidities, including respiratory distress syndrome (RDS), intraventricular hemorrhage (IVH), necrotizing enterocolitis (NEC) and sepsis, are inversely associated with gestational age at birth. Objective: This study aimed to decrease the morbidities and mortalities resulting from premature rupture of membrane (PROM). Patients and Methods: This was a cohort study, which was conducted at Obstetrics and Gynecology Department, Faculty of Medicine, Zagazig University Hospital. Patients were divided into two groups; Group A: 24 patients received 100 mg of recombinant human lactoferrin (RHLF) twice a day before meals. Group B: 24 patients received placebo medicine. All patients were subjected to detailed history taking, general examination. Obstetric transvaginal ultrasound had been performed to evaluate cervical length and funneling. Results: Mode of delivery in group (A) in 14 women (58.3%) was normal vaginal delivery (NVD) and in 10 (41.7%) was cesarean section (CS) while in group (B) 11 women (45.8%) was NVD and in 13 (54.2%) was CS. There was no statistically significant difference between groups where P=0.564. Lactoferrin had sensitivity of 62.5 with specificity 56.2 and positive and negative predictive value of 41.7 and 75 respectively, while the area under curve was 0.594 with p value of 0.222. Conclusion: Supplementation with lactoferrin may be an option to reduce the risk of premature rupture of membrane.
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