Ibrahim, I., El-Salkh, B., Shawki, N., Shadia, M., Abou El-Fotouh, H. (2002). Comparative study on the effect of Gliclazide and two Antidiabetic plants used in Folk Medicine on Albino Rat's fetuses. The Egyptian Journal of Hospital Medicine, 6(1), 80-98. doi: 10.21608/ejhm.2002.18851
Ibrahim G. Ibrahim; Boshra El-Salkh; Nagwa Shawki; M Shadia; Hala M. Abou El-Fotouh. "Comparative study on the effect of Gliclazide and two Antidiabetic plants used in Folk Medicine on Albino Rat's fetuses". The Egyptian Journal of Hospital Medicine, 6, 1, 2002, 80-98. doi: 10.21608/ejhm.2002.18851
Ibrahim, I., El-Salkh, B., Shawki, N., Shadia, M., Abou El-Fotouh, H. (2002). 'Comparative study on the effect of Gliclazide and two Antidiabetic plants used in Folk Medicine on Albino Rat's fetuses', The Egyptian Journal of Hospital Medicine, 6(1), pp. 80-98. doi: 10.21608/ejhm.2002.18851
Ibrahim, I., El-Salkh, B., Shawki, N., Shadia, M., Abou El-Fotouh, H. Comparative study on the effect of Gliclazide and two Antidiabetic plants used in Folk Medicine on Albino Rat's fetuses. The Egyptian Journal of Hospital Medicine, 2002; 6(1): 80-98. doi: 10.21608/ejhm.2002.18851
Comparative study on the effect of Gliclazide and two Antidiabetic plants used in Folk Medicine on Albino Rat's fetuses
1Zoology department, Faculty of Science, Al – Azhar University for boys.
2Zoology department, Faculty of Science, Al – Azhar University for girls.
3Faculty of Pharmacy Cairo University.
Abstract
The present study was designed to assess the adverse effects of gliclazide and two antidiabetic plants extracts on 15 &18 days fetuses of albino rat (Rattus norvegicus). The two antidiabetic plants extracts were aquatic extract of Aremisia herba alba (shih-balady) and alcoholic extract of Salix babylonica L. leaves (Om-Ashoor) which is known by salicin. The doses used were 4 mg / kg (Katsumata, and kastumata 1990) for the gliclazide drug (diamicron), 450 mg/kg for Artemisia herba alba (Al-Waili, 1986) and 1.5 gm/kg for salicin. Pregnant rats were given orally the applied does level every other day from the onset of gestation till the 15th or to the 18th day. The pregnant rats were divided into control group (G1); diabetic pregnant female rats (G2); Artemisia treated group (G3); salicin treated group (G4) and glicalzide treated group (G5). Fetuses showed diminution of size. Crown-rump lentght while the number of embryos increased in case of salicin treatment and decreased in case of gliclazide treatment due to increased resorption rate. The endoskeleton system of fetuses obtained from pregnant diabetic mothers (G2) showed normal ossification in all fetuses with enlarged skeleton. Some fetuses of Artemisia treated group showed major enoskeletal anomalies in the from of incomplete ossification of the skull bones, or missing in some skull bones, and also missing of caudal vertebrae. Salicin treated group fetuses showed lack in ossification of the nasal, frontal and complete absence of parietal bone. While gliclazide treated group fetuses showed moderate ossification of nasal and frontal bones. On the other hand parietal bone exhibited complete missing.
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