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MS, G., AM, O., MM, E., Somaia.A, N. (2004). Prophylactic effect of tamoxifen against induction of mammary carcinoma. The Egyptian Journal of Hospital Medicine, 14(1), 104-114. doi: 10.21608/ejhm.2004.18225
Gabri MS; Osman AM; El-Sayed MM; Negm Somaia.A. "Prophylactic effect of tamoxifen against induction of mammary carcinoma". The Egyptian Journal of Hospital Medicine, 14, 1, 2004, 104-114. doi: 10.21608/ejhm.2004.18225
MS, G., AM, O., MM, E., Somaia.A, N. (2004). 'Prophylactic effect of tamoxifen against induction of mammary carcinoma', The Egyptian Journal of Hospital Medicine, 14(1), pp. 104-114. doi: 10.21608/ejhm.2004.18225
MS, G., AM, O., MM, E., Somaia.A, N. Prophylactic effect of tamoxifen against induction of mammary carcinoma. The Egyptian Journal of Hospital Medicine, 2004; 14(1): 104-114. doi: 10.21608/ejhm.2004.18225

Prophylactic effect of tamoxifen against induction of mammary carcinoma

Article 10, Volume 14, Issue 1, January 2004, Page 104-114  XML PDF (840.34 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2004.18225
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Authors
Gabri MS1; Osman AM2; El-Sayed MM2; Negm Somaia.A2
1Department of Zoology, faculty of science, Helwan University
2Pharmacology and Experimental therapeutic Unit, Cancer biology Dep., National Cancer Institute, Cairo University
Abstract
Tamoxifen (TAM) is a potent anticancer agent known to interrupt the enhanced estrogen activity of malignant mammary gland cells, The mechanism of tamoxifen’s anti-tumor activity is primarily due to its anti estrogen action. Female Swiss albino mice were used in the present study and divided into:- normal control group, two Ehrlich ascites carcinoma (EAC) control groups [treated interaperitonealy(IP) and subcutaneously (Sc)], tamoxifen treated only group, tamoxifen pre treated then EAC (S.C) injected group and tamoxifen pre treated then EAC (I.P) injected group.
The present results showed a significant decrease in tumor volume and a significant increase in the survival time in the pre-treated group compared to untreated group. There was a pathological change in the uterine tissues of the tamoxifen treated mice in the form of squamous metaplasia and dysplasia of glandular epithelial . The kidney tissues showed a minimal pathological change in the form of a focal renal lesion in the renal tubular epithelium. in conclusion the present study showed that tamoxifen has a prophylactic effect against experimental mammary carcinoma. And exerts some side effects on the histopathological structure of the uterine and kidney tissues. Key words: Tamoxifen, Mammary carcinoma, experimental, prophylactic, side effect.
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