Home Articles List Article Information
The Egyptian Journal of Hospital Medicine
Journal Archive
Volume Volume 97 (2024)
Volume Volume 96 (2024)
Volume Volume 95 (2024)
Volume Volume 94 (2024)
Volume Volume 93 (2023)
Volume Volume 92 (2023)
Volume Volume 91 (2023)
Volume Volume 90 (2023)
Volume Volume 89 (2022)
Volume Volume 88 (2022)
Volume Volume 87 (2022)
Volume Volume 86 (2022)
Volume Volume 85 (2021)
Volume Volume 84 (2021)
Volume Volume 83 (2021)
Volume Volume 82 (2021)
Volume Volume 81 (2020)
Volume Volume 80 (2020)
Volume Volume 79 (2020)
Volume Volume 78 (2020)
Volume Volume 77 (2019)
Volume Volume 76 (2019)
Volume Volume 75 (2019)
Volume Volume 74 (2019)
Volume Volume 73 (2018)
Volume Volume 72 (2018)
Volume Volume 71 (2018)
Volume Volume 70 (2018)
Volume Volume 69 (2017)
Volume Volume 68 (2017)
Volume Volume 67 (2017)
Volume Volume 66 (2017)
Volume Volume 65 (2016)
Volume Volume 64 (2016)
Volume Volume 63 (2016)
Volume Volume 62 (2016)
Volume Volume 61 (2015)
Volume Volume 60 (2015)
Volume Volume 59 (2015)
Volume Volume 58 (2015)
Volume Volume 57 (2014)
Volume Volume 56 (2014)
Volume Volume 55 (2014)
Volume Volume 54 (2014)
Volume Volume 53 (2013)
Volume Volume 52 (2013)
Volume Volume 51 (2013)
Volume Volume 50 (2013)
Volume Volume 49 (2012)
Volume Volume 48 (2012)
Volume Volume 47 (2012)
Volume Volume 46 (2012)
Volume Volume 45 (2011)
Volume Volume 44 (2011)
Volume Volume 43 (2011)
Volume Volume 42 (2011)
Volume Volume 41 (2010)
Volume Volume 40 (2010)
Volume Volume 39 (2010)
Volume Volume 38 (2010)
Volume Volume 37 (2009)
Volume Volume 36 (2009)
Volume Volume 35 (2009)
Volume Volume 34 (2009)
Volume Volume 33 (2008)
Volume Volume 32 (2008)
Volume Volume 31 (2008)
Volume Volume 30 (2008)
Volume Volume 29 (2007)
Volume Volume 28 (2007)
Volume Volume 27 (2007)
Volume Volume 26 (2007)
Volume Volume 25 (2006)
Volume Volume 24 (2006)
Volume Volume 23 (2006)
Volume Volume 22 (2006)
Volume Volume 21 (2005)
Volume Volume 20 (2005)
Volume Volume 19 (2005)
Volume Volume 18 (2005)
Volume Volume 17 (2004)
Volume Volume 16 (2004)
Volume Volume 15 (2004)
Volume Volume 14 (2004)
Volume Volume 13 (2003)
Volume Volume 12 (2003)
Volume Volume 11 (2003)
Volume Volume 10 (2003)
Volume Volume 9 (2002)
Volume Volume 8 (2002)
Volume Volume 7 (2002)
Volume Volume 6 (2002)
Volume Volume 5 (2001)
Volume Volume 4 (2001)
Volume Volume 3 (2001)
Volume Volume 2 (2001)
Volume Volume 1 (2000)
Ashour, A., Ahmed, S., A.S, M., H. G, Z. (2004). Immunoprophylactic effect of single and mixed schistosomal antigens on Schistosoma mansoni infected mice. The Egyptian Journal of Hospital Medicine, 14(1), 86-103. doi: 10.21608/ejhm.2004.18224
Ameen A. Ashour; Samia A. Ahmed; Maghraby A.S; Zahran H. G. "Immunoprophylactic effect of single and mixed schistosomal antigens on Schistosoma mansoni infected mice". The Egyptian Journal of Hospital Medicine, 14, 1, 2004, 86-103. doi: 10.21608/ejhm.2004.18224
Ashour, A., Ahmed, S., A.S, M., H. G, Z. (2004). 'Immunoprophylactic effect of single and mixed schistosomal antigens on Schistosoma mansoni infected mice', The Egyptian Journal of Hospital Medicine, 14(1), pp. 86-103. doi: 10.21608/ejhm.2004.18224
Ashour, A., Ahmed, S., A.S, M., H. G, Z. Immunoprophylactic effect of single and mixed schistosomal antigens on Schistosoma mansoni infected mice. The Egyptian Journal of Hospital Medicine, 2004; 14(1): 86-103. doi: 10.21608/ejhm.2004.18224

Immunoprophylactic effect of single and mixed schistosomal antigens on Schistosoma mansoni infected mice

Article 9, Volume 14, Issue 1, January 2004, Page 86-103  XML PDF (402.29 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2004.18224
View on SCiNiTO View on SCiNiTO
Authors
Ameen A. Ashour1; Samia A. Ahmed2; Maghraby A.S2; Zahran H. G2
1Zoology Department, Ain-Shams University, Cairo, Egypt.
2Therapeutical Chemistry Department, National Research Centre , Cairo, Egypt
Abstract
B This study aimed to detect the cellular, humoral immune responses and protection against schistosomes induced by cercarial (CAP), soluble worm (SWAP), soluble egg (SEA), and mixed (SEA + CAP), (SEA + SWAP) and (CAP + SWAP) antigens to Schistosoma mansoni infection in mice, and the improvement in the liver enzyme activities before and after challenge with S. mansoni. Each mouse was sensitized with an initial immunization of 0.6 ml of the extracted antigen (30μg protein/ml). After one week, a second injection of 0.4 ml was given (20μg protein/ml). Then, each mouse was exposed to 80 cercariae. Six weeks post challenge the protection percentage was 42.5, 58.33, 53.33, 60.91, 78.16 and 64.77% for CAP, SEA, SWAP, (SEA +CAP), (SEA+SWAP) and (CAP + SWAP), respectively. The results revealed a high significant interrelation between number of lymph node cells (MLN) (P0.001), splenocytes (P0.04) and thymocytes (P0.001) that obtained with each immunized group compared to controls. A high significant difference (P0.001) between levels of IgG obtained between different antigen groups and the control before and after challenge. The immunization with previous antigens resulted in a remarkable improvement in the liver enzyme activities, which were disturbed after infection. Thus, vaccination of mice with the previous different antigens has an immunoprophylactic effect and may protect liver against infection through reduction in worm burden leading to the improvement of many liver enzymes.

Keywords
Liver, Mesenteric lymph nodes, Schistosoma mansoni; Splenocytes, Thymocytes
Statistics
Article View: 142
PDF Download: 397