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Helal, E., El- Shafaey, M., Rahoma, H., Abdel- Rahman, M. (2004). Effect of Systemic Lupus Erythematosus on some Biochemical Parameters in Female Patients. The Egyptian Journal of Hospital Medicine, 17(1), 187-196. doi: 10.21608/ejhm.2004.18167
Eman G.E Helal; Medhat El- Shafaey; Hala Rahoma; Mervat Abdel- Rahman. "Effect of Systemic Lupus Erythematosus on some Biochemical Parameters in Female Patients". The Egyptian Journal of Hospital Medicine, 17, 1, 2004, 187-196. doi: 10.21608/ejhm.2004.18167
Helal, E., El- Shafaey, M., Rahoma, H., Abdel- Rahman, M. (2004). 'Effect of Systemic Lupus Erythematosus on some Biochemical Parameters in Female Patients', The Egyptian Journal of Hospital Medicine, 17(1), pp. 187-196. doi: 10.21608/ejhm.2004.18167
Helal, E., El- Shafaey, M., Rahoma, H., Abdel- Rahman, M. Effect of Systemic Lupus Erythematosus on some Biochemical Parameters in Female Patients. The Egyptian Journal of Hospital Medicine, 2004; 17(1): 187-196. doi: 10.21608/ejhm.2004.18167

Effect of Systemic Lupus Erythematosus on some Biochemical Parameters in Female Patients

Article 15, Volume 17, Issue 1, October 2004, Page 187-196  XML PDF (364.59 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2004.18167
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Authors
Eman G.E Helal1; Medhat El- Shafaey2; Hala Rahoma2; Mervat Abdel- Rahman3
1Zoology Department, Faculty of Science, Al- Azhar University (Girls)
2Clinical Immunology and Allergy Department, Faculty of Medicine, Ain- Shams University.
3Clinical Pathology Lab., Student Hospital, Cairo University.
Abstract
It has been noticed that there is an increase in the number of women suffering from SLE. Most studies confirmed that serum DHEA (dehydroepiandrosterone) and DHEA sulphate are lower among patients with SLE than among controls even- during phases of inactive disease so we performed this study to detect the level of DHEA-S in the female patients with SLE. The overall results confirm that DHEA treatment was well- tolerated, significantly reduced the number of SLE flares, and improved patient’s global assessment of disease activity. Some serum parameters like liver and kidney functions were detected. Biochemical analysis showed that there is a significant increase of total lipids, cholestrol, triglycerides. But insignificant change in serum glucose, urea nitrogen and uric acid levels were recorded. From the present study three things were concluded. Firstly, there is a strong relationship between level of DHEA and the progression of SLE. Secondly, liver activity and kidney functions were not affected by SLE disease.Thirdly, DHEA treatment has a beneficial effect on female patients. So this study recommended to follow up DHEAS in female patients and use it in a proper dosage. In addition, further study must be done.
 
Keywords
SLE; DHEA; Liver functions; kidney functions
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