Serum level of IL13 and expression of BCL2 in Behcet’s disease

Darwish, Hanan.M.A; Mousa, Sabila Gomaa; Hamdy, Noha; Zalam, Sahar

doi:10.21608/ejhm.2006.17922

Serum level of IL13 and expression of BCL2 in Behcet’s disease

Document Type : Original Article

Authors

¹ Departments of Dermatology and Venereology Faculty of Medicine for girls Al-Azhar University.

² General Medicine Faculty of Medicine for girls Al-Azhar University.

³ Clinical Pathology, Faculty of Medicine for girls Al-Azhar University.

⁴ Clinical Pathology,Faculty of Medicine for girls Al-Azhar University.

10.21608/ejhm.2006.17922

Abstract

Background BD: BCL2 family is a large family of apoptosis regulating proteins consisting of both blockers and promoters of cell death. Immunological processes and a variety of cytokines may play a role in pathophysiological process. Defective regulation of programmed cell death (apoptosis) also play a role in development of Behcet’s disease
Objective: To investigate the level of BCL2 and IL13in BD and to determine their to relation monitory disease activity.
Patients and methods: This study was conducted on thirty patients (15 active and 15 inactive) and 15-health control, the activity of BD was evaluated according to international study group for BD disease, using ELISA technique for IL 13 and flow cytometry forBCL2.
Results: Elevated serum levels of IL13 in patient with active BD than inactive and both had elevated levels than control(P< 0.01) and also the serum levels of Bcl2 was elevated in patient with active BD than inactive and control(P< 0.01).
Concolusion: The data suggested that IL13 and BCL2 could be involved in the pathogenesis of BD and its serum levels can be used as marker to monitor disease activity.