Hassanein, M., Hegab, M., Attia, A., Zayed, M. (2018). Extended Letrozole Therapy for Ovulation Induction in clomiphene resistant Women with Polycystic Ovary Syndrome. The Egyptian Journal of Hospital Medicine, 73(7), 7032-7036. doi: 10.21608/ejhm.2018.17230
Mohammad Salah El-Dein Hassanein; Mostafa Hussein Hegab; Attia Mohammad Attia; Mostafa Ahmed Abd El-Maksoud Zayed. "Extended Letrozole Therapy for Ovulation Induction in clomiphene resistant Women with Polycystic Ovary Syndrome". The Egyptian Journal of Hospital Medicine, 73, 7, 2018, 7032-7036. doi: 10.21608/ejhm.2018.17230
Hassanein, M., Hegab, M., Attia, A., Zayed, M. (2018). 'Extended Letrozole Therapy for Ovulation Induction in clomiphene resistant Women with Polycystic Ovary Syndrome', The Egyptian Journal of Hospital Medicine, 73(7), pp. 7032-7036. doi: 10.21608/ejhm.2018.17230
Hassanein, M., Hegab, M., Attia, A., Zayed, M. Extended Letrozole Therapy for Ovulation Induction in clomiphene resistant Women with Polycystic Ovary Syndrome. The Egyptian Journal of Hospital Medicine, 2018; 73(7): 7032-7036. doi: 10.21608/ejhm.2018.17230
Extended Letrozole Therapy for Ovulation Induction in clomiphene resistant Women with Polycystic Ovary Syndrome
1Department Of Obstetrics and Gynecology, Al-Azhar Faculty of Medicine, Cairo
2Obstetrics and Gynecology at Manshiet El-Bakry General Hospital
Abstract
Objective: This study aimed to evaluate the efficacy of short and extended long course of letrozole therapy for ovulation induction in clomiphene resistant women with polycystic ovary syndrome. Patients: One hundred infertile women were selected from the patients attending the outpatient clinic of Manshiet El-Bakry general hospital. All patients were diagnosed as having anovulation due to polycystic ovary syndrome (PCOS). Interventions: Patients were randomly allocated to treatment with either long letrozole group took 2.5 mg of letrozole daily starting day 1 of spontaneous or progesterone inducing menstrual bleeding for 10 days (50 patients, up to 3 cycles) or short letrozole group took 5 mg of letrozole daily starting day 1 of spontaneous or progesterone inducing menstrual bleeding for 5 days (50 patients, up to 3 cycles). Results:The number of ovulating patients was greater in the long letrozole group (74% vs. 56%), but without statistical differences. The total number of follicles during stimulation was insignificantly greater in the long letrozole group (8.2 vs. 8.17). The numbers of follicles ≥18 mm were significantly greater in the long letrozole group. Pregnancy occurred in 7 in the short group (14%) and 12 of (24%) in the long letrozole group, and the difference was statistically insignificant. Conclusion: The long letrozole protocol (10 days) can produce more mature follicles and subsequently more pregnancies than the short letrozole therapy (5 days).
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