Relationship between HCV infection and Insulin resistance in non-obese non- diabetic patients

Document Type : Original Article

Authors

1 Department of Community, Environmental and Occupational Medicine, Faculty of Medicine, Ain Shams University.

2 Department of Tropical Medicine, Cairo University

3 Viral Hepatitis Research Laboratory, National Hepatology and Tropical Medicine Research Institute

4 Department of Tropical Medicine, National Hepatology and Tropical Medicine Research Institute.

5 Department of Clinical pathology, Hearing and Speech Institute, Egypt.

6 Department of Clinical pathology, Faculty of Medicine, Bani Sewif University.

Abstract

Background:HepatitisCisamajorcauseofliver-relatedmorbidityandmortalityandrepresentsa majorpublichealthprobleminEgyptandworldwide.Thereisgrowingevidenceasregardtothe associationbetweenhepatitisCvirus(HCV)infectionandtype2diabetesmellitus.However,the mutuallinkandrelatedvirologicalimplicationhavenotbeenfullyclarified.Insulinresistance(IR) playsaprimaryroleinthedevelopmentoftype2DM.Thisissupportedbytheresultsofprospective longitudinalstudiesshowingthatIRisthebestpredictorofthedevelopmentoftype2DM,preceding itsonsetby10-20years.
Aim:ToassessthecorrelationbetweenHCVmorbidityandInsulinresistance(IR)detectedby HOMAtestinnonediabeticnoneobeseHCVpatients
Materials&Method:Thestudyparticipantsweresubcategorizedintotwogroups,Group(I): included867healthysubjects(negativeHCVRNA)asacontrolgroup.Group(II):included277 patientswithchronicHCVasastudygroup.The2groupsweresubjectedtothoroughhistorytaking, fullclinicalexamination,Anthropometricstudy,ultrasonographicexaminationandlaboratory investigationsincludingliverfunctions,viralmarkers,andqualitativePCRforHCVRNA,lipid profile,glucoseprofileandHOMAtest.
Results:ThisstudyrevealedhigherinsulinresistanceintheHCVstudygroupthanthecontrolgroup.

Keywords

The Egyptian Journal of Hospital Medicine
Volume 41, Issue 1
October 2010
Pages 540-550

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