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Mohamed, M., Esmat, G., Said, M., Abdel Hamid, M., Hassany, M., Hassanein, M., El- Atrebi, K., El Gazzar, H., Omar, M. (2010). Relationship between HCV infection and Insulin resistance in non-obese non- diabetic patients. The Egyptian Journal of Hospital Medicine, 41(1), 540-550. doi: 10.21608/ejhm.2010.16953
Mostafa K. Mohamed; Gamal Esmat; Mohamed Said; Mohamed Abdel Hamid; Mohamed Hassany; Mohamad A. Hassanein; Kamal A. El- Atrebi; Helmy El Gazzar; M S. Omar. "Relationship between HCV infection and Insulin resistance in non-obese non- diabetic patients". The Egyptian Journal of Hospital Medicine, 41, 1, 2010, 540-550. doi: 10.21608/ejhm.2010.16953
Mohamed, M., Esmat, G., Said, M., Abdel Hamid, M., Hassany, M., Hassanein, M., El- Atrebi, K., El Gazzar, H., Omar, M. (2010). 'Relationship between HCV infection and Insulin resistance in non-obese non- diabetic patients', The Egyptian Journal of Hospital Medicine, 41(1), pp. 540-550. doi: 10.21608/ejhm.2010.16953
Mohamed, M., Esmat, G., Said, M., Abdel Hamid, M., Hassany, M., Hassanein, M., El- Atrebi, K., El Gazzar, H., Omar, M. Relationship between HCV infection and Insulin resistance in non-obese non- diabetic patients. The Egyptian Journal of Hospital Medicine, 2010; 41(1): 540-550. doi: 10.21608/ejhm.2010.16953

Relationship between HCV infection and Insulin resistance in non-obese non- diabetic patients

Article 8, Volume 41, Issue 1, October 2010, Page 540-550  XML PDF (1.53 MB)
Document Type: Original Article
DOI: 10.21608/ejhm.2010.16953
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Authors
Mostafa K. Mohamed1; Gamal Esmat2; Mohamed Said2; Mohamed Abdel Hamid3; Mohamed Hassany4; Mohamad A. Hassanein4; Kamal A. El- Atrebi4; Helmy El Gazzar5; M S. Omar6
1Department of Community, Environmental and Occupational Medicine, Faculty of Medicine, Ain Shams University.
2Department of Tropical Medicine, Cairo University
3Viral Hepatitis Research Laboratory, National Hepatology and Tropical Medicine Research Institute
4Department of Tropical Medicine, National Hepatology and Tropical Medicine Research Institute.
5Department of Clinical pathology, Hearing and Speech Institute, Egypt.
6Department of Clinical pathology, Faculty of Medicine, Bani Sewif University.
Abstract
Background:HepatitisCisamajorcauseofliver-relatedmorbidityandmortalityandrepresentsa majorpublichealthprobleminEgyptandworldwide.Thereisgrowingevidenceasregardtothe associationbetweenhepatitisCvirus(HCV)infectionandtype2diabetesmellitus.However,the mutuallinkandrelatedvirologicalimplicationhavenotbeenfullyclarified.Insulinresistance(IR) playsaprimaryroleinthedevelopmentoftype2DM.Thisissupportedbytheresultsofprospective longitudinalstudiesshowingthatIRisthebestpredictorofthedevelopmentoftype2DM,preceding itsonsetby10-20years.
Aim:ToassessthecorrelationbetweenHCVmorbidityandInsulinresistance(IR)detectedby HOMAtestinnonediabeticnoneobeseHCVpatients
Materials&Method:Thestudyparticipantsweresubcategorizedintotwogroups,Group(I): included867healthysubjects(negativeHCVRNA)asacontrolgroup.Group(II):included277 patientswithchronicHCVasastudygroup.The2groupsweresubjectedtothoroughhistorytaking, fullclinicalexamination,Anthropometricstudy,ultrasonographicexaminationandlaboratory investigationsincludingliverfunctions,viralmarkers,andqualitativePCRforHCVRNA,lipid profile,glucoseprofileandHOMAtest.
Results:ThisstudyrevealedhigherinsulinresistanceintheHCVstudygroupthanthecontrolgroup.
Keywords
HCV-Insulinresistance; HOMA test
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