Structural and laboratory changes in the liver of female albino rats in cases of experimental high fat diet and curative role of some medicinal plants.

Document Type : Original Article

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Histology Departments, Faculty of Medicine Al-Azhar University

Abstract

High fat diets as well as hyperlipidemia represent an important clinical and social problem. It is referred to increased concentration of lipids (Triglycerides, Cholesterol and Fatty acids) in the blood. Such increase may lead to metabolic risks affecting blood vessels and paranchymatous organ mainly the liver.
 
Material and methods:  Forty five adult female albino rats were used and divided into 9 equal groups. The first group was considered as a control group. The second group was of high fat diet (25% fat and 2% cholesterol) for 3 weeks. Groups 3,4 and 5 were similar to the second group but received  three medicinal plants respectively Oat ,Fennel and Triphala. The sixth group was also of high fat diet but for 6 weeks. Groups 7, 8 and 9 were treated with same medicinal plants as groups 3, 4 and 5.
Two main parameters were performed; the first was microscopic study of the liver tissue while the second was laboratory evaluation of liver functions.
 
Results: The hepatic tissue greatly affected by the induction of high fat diet in the form of variable grades of fatty infiltration and vascular congestion either after 3 or 6 weeks of induction. Fibrous content and PAS +ve material were also affected. Structural changes were confirmed by laboratory data.
 
Conclusions: Medicinal plants and regulation of diet quality plays a good role in limiting the risk of fatty liver and atherosclerosis.
 
 
 

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