Antioxidant effect of Flaxseed against liver Cirrhosis induced in Thioacetamide intoxicated rats

Document Type : Original Article

Authors

1 Chemistry department, HelwanUniversity,Egypt.

2 Nutritional Biochemistry, National Nutrition Institute, Egypt.

Abstract

Background/Aim:There has been a current upsurge in the medical implications of free radicals and related species during the past several decades. These chemical species are integral components produced during normal biochemical and physiological processes but leads to oxidative stress when produce in excess and causes potential damage to cells. A wide range of non-enzymatic and enzymatic antioxidant defenses exists to counteract the damaging effects of free radicals. There exist epidemiological evidences correlating higher intake of antioxidant rich foodstuffs with greater free radical neutralizing potential to lower incidence of several human morbidities or mortalities.
 
Material andMethods: liver cirrhosis model was induced by TAA,hepatobichemical and antioxidant parameters were assayed.
Results: Flaxseed induced enhancement in liver function test, antioxidant status and lipid profile.
Conclusion: Flaxseed can be used as hepatoprotective against liver cirrhosis induced with TAA as compared to reference drug Silymaringroup.
 

Keywords

The Egyptian Journal of Hospital Medicine
Volume 51, Issue 1
April 2013
Pages 448-460

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