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EL Baz, R., Ramadan, M., Fayad, E., Shaltot, A., Shershaby, E. (2014). Comparative Study on the Effect of Factor V Leiden and Prothrombin Gene Polymorphism in Preeclampsic Cases. The Egyptian Journal of Hospital Medicine, 56(1), 345-354. doi: 10.21608/ejhm.2014.15693
Rizk Ahmed EL Baz; Manal Mohamed Ramadan; Eman Fayad; Ali Ali Shaltot; Effat Mahmoud EL Shershaby. "Comparative Study on the Effect of Factor V Leiden and Prothrombin Gene Polymorphism in Preeclampsic Cases". The Egyptian Journal of Hospital Medicine, 56, 1, 2014, 345-354. doi: 10.21608/ejhm.2014.15693
EL Baz, R., Ramadan, M., Fayad, E., Shaltot, A., Shershaby, E. (2014). 'Comparative Study on the Effect of Factor V Leiden and Prothrombin Gene Polymorphism in Preeclampsic Cases', The Egyptian Journal of Hospital Medicine, 56(1), pp. 345-354. doi: 10.21608/ejhm.2014.15693
EL Baz, R., Ramadan, M., Fayad, E., Shaltot, A., Shershaby, E. Comparative Study on the Effect of Factor V Leiden and Prothrombin Gene Polymorphism in Preeclampsic Cases. The Egyptian Journal of Hospital Medicine, 2014; 56(1): 345-354. doi: 10.21608/ejhm.2014.15693

Comparative Study on the Effect of Factor V Leiden and Prothrombin Gene Polymorphism in Preeclampsic Cases

Article 9, Volume 56, Issue 1, July 2014, Page 345-354  XML PDF (366.85 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2014.15693
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Authors
Rizk Ahmed EL Baz1; Manal Mohamed Ramadan2; Eman Fayad3; Ali Ali Shaltot1; Effat Mahmoud EL Shershaby2
1Faculty of Medicine, Genetic department at MansouraUniversity
2Faculty of Science, Zoology department at Mansoura University
3Faculty of Medicine, Genetic department at MansouraUniversity.
Abstract
Objective: To identify polymorphism of Factor V Leiden and Prothrombin gene in women suffering from preeclampsia.
                        Study design:   From 142 pregnant women we identified 92 women suffering from preeclampsia and 50 healthy controls with normal pregnancy matched for age and socioeconomic status, preeclampsic patient classified as mild preeclampsia 42(45.7%) and severe preeclampsia 50(54.3%). Blood samples were tested for DNA polymorphism affecting thrombophilia Factor V Leiden and Prothrombin gene polymorphism.
                        Results:   Heterozygous AG genotype showed a significant high frequency among preeclampsic patients (20.7%) compared to controls (4.0%), (OR 6.2, P= 0.006) regarding to Prothrombin gene but: Factor V Leiden, AG genotype showed (8.7%) of preeclampsic patients which was absent in any of the controls.
 
Keywords
Factor V Leiden; Prothrombin gene; preeclampsia
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