Comparative Study on the Effect of Factor V Leiden and Prothrombin Gene Polymorphism in Preeclampsic Cases

Document Type : Original Article

Authors

1 Faculty of Medicine, Genetic department at MansouraUniversity

2 Faculty of Science, Zoology department at Mansoura University

3 Faculty of Medicine, Genetic department at MansouraUniversity.

Abstract

Objective: To identify polymorphism of Factor V Leiden and Prothrombin gene in women suffering from preeclampsia.
                        Study design:   From 142 pregnant women we identified 92 women suffering from preeclampsia and 50 healthy controls with normal pregnancy matched for age and socioeconomic status, preeclampsic patient classified as mild preeclampsia 42(45.7%) and severe preeclampsia 50(54.3%). Blood samples were tested for DNA polymorphism affecting thrombophilia Factor V Leiden and Prothrombin gene polymorphism.
                        Results:   Heterozygous AG genotype showed a significant high frequency among preeclampsic patients (20.7%) compared to controls (4.0%), (OR 6.2, P= 0.006) regarding to Prothrombin gene but: Factor V Leiden, AG genotype showed (8.7%) of preeclampsic patients which was absent in any of the controls.
 

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