Protective Effects of Curcumin for Oxidative Stress and Histological Alterations Induced by Pyrethroid Insecticide in Albino Rats

Abdel Rheim, Fouad; Ragab, Awad Abbas; Hammam, Fatma .M.; Hamdy, Hossam El-Din

doi:10.12816/0009362

Protective Effects of Curcumin for Oxidative Stress and Histological Alterations Induced by Pyrethroid Insecticide in Albino Rats

Document Type : Original Article

Authors

¹ Department of biochemistry, Faculty of Agriculture, Cairo University

² Department of Mammalin Toxicology , Central Agriculture pesticidesLaboratory Agricultural Research Central

10.12816/0009362

Abstract

Background:esfenvalerate(esfen) is a type II of synthetic pyrethroid that has replaced other groups of insecticides due to its improved insecticidal potency. The objective of this study was to investigate the toxicity of pyrethroid insecticides on liver tissues of rats and the possible role of antioxidant plant (curcumin ) as a protective agent against oxidative stress and histological alterations.
Material and methods: forty male albino rats were divided into 8 groups of 5 rats /each: G1: served as control and G2: served as positive control received (100mg/kg curcumin ), G3,G4 and G5 had oral administration (1/20 LD50, 1/40 LD50 and 1/60 LD50 of esfenvelerate ) respectively and the last three groups(G6,G7and G8) were received the same doses of pesticide plus 100mg /kg curcumin for 28 days daily.
Results: exposure of rats to (esfen) induced significant increase in the levels of MDA and significant decrease in total protein , GSH ,SOD and catalase whilst the insecticides doses plus curcumin showed decrease in MDA for high and medium dose and ameliorated the reduction of total protein concentration in low dose. We showed that curcumin acts as an effective antioxidant for esfen pesticide toxicity by reducing oxidative stress burden and histological damage.

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