Kandila, A., S, G., Farrag, A., Hassan, B., I. S, D. (2015). Histological Study and DNA Changes in the Kidneys of Rat Fetuses Maternally Treated with Clarithromycin. The Egyptian Journal of Hospital Medicine, 61(1), 575-590. doi: 10.12816/0018762
Asmaa M. Kandila; Gabri M. S; Abdel Razik H. Farrag; Basma N. Hassan; Doaa Ezz-Eldin I. S. "Histological Study and DNA Changes in the Kidneys of Rat Fetuses Maternally Treated with Clarithromycin". The Egyptian Journal of Hospital Medicine, 61, 1, 2015, 575-590. doi: 10.12816/0018762
Kandila, A., S, G., Farrag, A., Hassan, B., I. S, D. (2015). 'Histological Study and DNA Changes in the Kidneys of Rat Fetuses Maternally Treated with Clarithromycin', The Egyptian Journal of Hospital Medicine, 61(1), pp. 575-590. doi: 10.12816/0018762
Kandila, A., S, G., Farrag, A., Hassan, B., I. S, D. Histological Study and DNA Changes in the Kidneys of Rat Fetuses Maternally Treated with Clarithromycin. The Egyptian Journal of Hospital Medicine, 2015; 61(1): 575-590. doi: 10.12816/0018762
Histological Study and DNA Changes in the Kidneys of Rat Fetuses Maternally Treated with Clarithromycin
1Pharmacology Department, National Organization for Drug Control and Research, Giza, Egypt
2Zoology and Entomology Department, Faculty of Science, Helwan University, Cairo, Egypt
3Pathology Department, Medical Research Division National Research Centre, Cairo, Egypt
Abstract
Introduction: macrolide antibiotics are a class of potent and well established antimicrobials that also possess anti-inflammatory and/or immunomodulatory properties. Because of their size, lower levels of macrolides are able to reach the developing fetuses. Materials and method: the pregnant rats were orally administered with clarithromycin at early and late gestational periods. The 20 day-old fetuses were dissected for excision of the kidney. Half of the kidney was processed and stained with H & E, PAS, Masson’s trichrome and Feulgen techniques then followed by morphometric measurements and statistical study. The other half of the kidney was preserved for DNA fragmentation assay.Results: This study revealed that clarithromycin administration to pregnant rats showed different histopathological, histochemical and DNA changes in the kidneys of their fetuses. Conclusion: Administration of the antimicrobial agent; clarithromycin at early and late gestational periods exhibits nephrotoxicity in the developing fetuses.
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