B N, H., A S, A., N A, A., M E, H. (2015). Histological and Immunohistochemical Study on the Effect of Bisphenol A on the Retina of Female Albino Rat. The Egyptian Journal of Hospital Medicine, 61(1), 570-574. doi: 10.12816/0018761
Hassan B N; Alazzouni A S; Al Jalaud N A; Hassan M E. "Histological and Immunohistochemical Study on the Effect of Bisphenol A on the Retina of Female Albino Rat". The Egyptian Journal of Hospital Medicine, 61, 1, 2015, 570-574. doi: 10.12816/0018761
B N, H., A S, A., N A, A., M E, H. (2015). 'Histological and Immunohistochemical Study on the Effect of Bisphenol A on the Retina of Female Albino Rat', The Egyptian Journal of Hospital Medicine, 61(1), pp. 570-574. doi: 10.12816/0018761
B N, H., A S, A., N A, A., M E, H. Histological and Immunohistochemical Study on the Effect of Bisphenol A on the Retina of Female Albino Rat. The Egyptian Journal of Hospital Medicine, 2015; 61(1): 570-574. doi: 10.12816/0018761
Histological and Immunohistochemical Study on the Effect of Bisphenol A on the Retina of Female Albino Rat
1Department of Zoology, Faculty of Science, Helwan University
2Department of Biology, Faculty of Science, Dammam University, Saudi Arabia
3Department of Ophthalmology, Faculty of Medicine, Al Azhar University
Abstract
Background: Bisphenol A (BPA) is a well-known endocrine disruptor used to manufacture polycarbonate plastics and epoxy resins. Exposure of rats to low doses of BPA results in histopathological effects in their retina. Objectives: We used histological and immunohistlogical techniques for determining retina pathological changes in response to low doses of BPA and the modulating effect of both vitamin A and stem enhancer. Methods: Twenty female albino rats orally administered with 20mg BPA /kgb.wt/day for 45 days and then divided to groups and treated with vitamin A and stem enhancer. Both eyes were examined histologically and immunohistochemicaly to determine the histopathological changes in retinal layers. Results: A remarkable degenerative histopathological changes in the ganglion cell layer and inner nuclear layer appeared with bis phenol treated rats and a clear improvement was seen after treatment with both vitamin A and stem cell enhancer. Conclusions: Both of vitamin A and stem enhancer have ameliorative effect on the degenerative changes in the retinal layers and damaged estrogen receptors by the action of bisphenol A.
View on SCiNiTO
Top