Alhalaby, A., Shehl, H., Abo Shady, H., El khouly, N. (2021). Effect of Use of Single Dose of Misoprostol on Blood Loss during Myomectomy. The Egyptian Journal of Hospital Medicine, 82(2), 296-301. doi: 10.21608/ejhm.2021.144577
Alaa Elden Fath Alah Alhalaby; Hend Ali Shehl; Heba Maged Abo Shady; Nabih Ibrahim El khouly. "Effect of Use of Single Dose of Misoprostol on Blood Loss during Myomectomy". The Egyptian Journal of Hospital Medicine, 82, 2, 2021, 296-301. doi: 10.21608/ejhm.2021.144577
Alhalaby, A., Shehl, H., Abo Shady, H., El khouly, N. (2021). 'Effect of Use of Single Dose of Misoprostol on Blood Loss during Myomectomy', The Egyptian Journal of Hospital Medicine, 82(2), pp. 296-301. doi: 10.21608/ejhm.2021.144577
Alhalaby, A., Shehl, H., Abo Shady, H., El khouly, N. Effect of Use of Single Dose of Misoprostol on Blood Loss during Myomectomy. The Egyptian Journal of Hospital Medicine, 2021; 82(2): 296-301. doi: 10.21608/ejhm.2021.144577
Effect of Use of Single Dose of Misoprostol on Blood Loss during Myomectomy
Department of Obstetrics and Gynecology, Faculty of Medicine, Menoufia University, Menoufia, Egypt
Abstract
Background: Uterine leiomyomas are the commonest benign tumours in women, which are estrogen-dependent and grow during the reproductive life. Standard treatment for leiomyoma is hysterectomy or myomectomy according to women's age and fertility. Prostaglandins and particularly PGE1 as misoprostol have an impact on uterine contractions and decrease blood loss. Objective: To evaluate the effect of using a single dose of vaginal misoprostol (400 Microgram) one hour before abdominal myomectomy on intraoperative blood loss. Materials and methods: This prospective randomized study was carried out postmenstrual upon 50 women with symptomatic uterine myoma who attended to Department of Obstetrics and Gynecology, Faculty of Medicine, Menoufia University during the period from October 2019 until October 2020. All subjects were divided into two equal groups: Misoprostol group included 25 women administered 400 mg misoprostol vaginally one hour before operation, and control group included 25 women underwent operation without misoprostol. Outcome variables included: intraoperative blood loss (ml), postoperative hemoglobin values, postoperative hematocrit values and operative time. Results: there was statistically significant difference between the two studied groups according to amount of intraoperative blood loss (ml) as Misoprostol group showed less blood loss than control group [(308.0 ± 32.66 vs. 404.4 ± 87), with p = 0.001]. In addition, there was statistically significant difference between the two studied groups regarding operative time as Misoprostol group showed shorter duration than control group [(56.8 ± 3.12 vs. 78.6 ± 10.6), with p=0.001]. Conclusion: A single dose of preoperative vaginal misoprostol is an effective method for reducing blood loss and operative time during abdominal myomectomy operations.
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