Abd El-Hakeem, E., Aly, A., Mahmoud, O., Hassan, A. (2021). Myocardial Protection with Glucose-Insulin-Potassium Infusion during Cardiopulmonary Bypass for Coronary Revascularization. The Egyptian Journal of Hospital Medicine, 82(2), 212-216. doi: 10.21608/ejhm.2021.140446
Essam Ezzat Abd El-Hakeem; Ahmed Elsaied Abd Elrahman Aly; Osama Salah El Din Mahmoud; Ahmad Hamody Hassan. "Myocardial Protection with Glucose-Insulin-Potassium Infusion during Cardiopulmonary Bypass for Coronary Revascularization". The Egyptian Journal of Hospital Medicine, 82, 2, 2021, 212-216. doi: 10.21608/ejhm.2021.140446
Abd El-Hakeem, E., Aly, A., Mahmoud, O., Hassan, A. (2021). 'Myocardial Protection with Glucose-Insulin-Potassium Infusion during Cardiopulmonary Bypass for Coronary Revascularization', The Egyptian Journal of Hospital Medicine, 82(2), pp. 212-216. doi: 10.21608/ejhm.2021.140446
Abd El-Hakeem, E., Aly, A., Mahmoud, O., Hassan, A. Myocardial Protection with Glucose-Insulin-Potassium Infusion during Cardiopulmonary Bypass for Coronary Revascularization. The Egyptian Journal of Hospital Medicine, 2021; 82(2): 212-216. doi: 10.21608/ejhm.2021.140446
Myocardial Protection with Glucose-Insulin-Potassium Infusion during Cardiopulmonary Bypass for Coronary Revascularization
1Department of Anesthesia, Intensive Care and Pain Management, Faculty of Medicine, Assiut University
2Department of Anesthesia, Intensive Care and Pain Management, Faculty of Medicine, Sohag University, Egypt
Abstract
Background: Sodi-Pallares and colleagues first time introduced use of glucose-insulin and potassium (GIK) solution for myocardial protection. They used this solution in patients with acute myocardial infarction and concluded that GIK solution limited electrocardiographic changes in these patients. Objective: To investigate the effectiveness of the GIK solution regarding myocardial protection evaluated by postoperative creatine kinase MB (CKMB) and cardiac troponin I levels. Method: In this prospective, randomized clinical trial, sixty-four patients were assigned into two groups: GIK group, in which glucose-insulin and potassium infusion were given during surgery, and non-GIK group in which only saline infusion was given during the procedure. Results: All CK-MB values were lower in the GIK group than the Non-GIK group in the postoperative period (6, 12 and 24 hours’ samples) with statistically significant results. Troponin values were lower in the GIK group versus the Non-GIK group after 6 and 12 hours with statistical significance (P < 0.001 and 0.022 respectively). Conclusion: The addition of GIK infusion throughout the operation to standard myocardial protective techniques in patients undergoing on-pump coronary artery bypass graft (CABG) surgery attenuates myocardial ischemic injury.
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