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Abd-Elhafiz, H., Issa, N. (2021). The Adjuvant Protective Effect of Resveratrol on Cisplatin-Induced Liver Toxicity in Male Albino Rats. The Egyptian Journal of Hospital Medicine, 82(1), 164-173. doi: 10.21608/ejhm.2021.139651
Huda I. Abd-Elhafiz; Noha M. Issa. "The Adjuvant Protective Effect of Resveratrol on Cisplatin-Induced Liver Toxicity in Male Albino Rats". The Egyptian Journal of Hospital Medicine, 82, 1, 2021, 164-173. doi: 10.21608/ejhm.2021.139651
Abd-Elhafiz, H., Issa, N. (2021). 'The Adjuvant Protective Effect of Resveratrol on Cisplatin-Induced Liver Toxicity in Male Albino Rats', The Egyptian Journal of Hospital Medicine, 82(1), pp. 164-173. doi: 10.21608/ejhm.2021.139651
Abd-Elhafiz, H., Issa, N. The Adjuvant Protective Effect of Resveratrol on Cisplatin-Induced Liver Toxicity in Male Albino Rats. The Egyptian Journal of Hospital Medicine, 2021; 82(1): 164-173. doi: 10.21608/ejhm.2021.139651

The Adjuvant Protective Effect of Resveratrol on Cisplatin-Induced Liver Toxicity in Male Albino Rats

Article 28, Volume 82, Issue 1, January 2021, Page 164-173  XML PDF (914.47 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2021.139651
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Authors
Huda I. Abd-Elhafiz; Noha M. Issa email
Abstract
Background: Cisplatin is antineoplastic drug associated with hepatotoxicity due to oxidative stress. Resveratrol has antioxidant effect so it could protect the liver cell. Objective: the aim of this work was to investigate the possible protective effects of resveratrol on hepatotoxicity caused by cisplatin drug in rats.
Materials and Methods: forty male albino rats were randomly divided into four groups: group I (control group): was maintained throughout the experiment without any treatment. Group II (resveratrol group) that received resveratrol daily in a dose of 25 mg/kg intraperitoneally for 21 days. Group III (cisplatin group) that received single intraperitoneal injection of cisplatin in a dose of 7.5 mg/kg at the 16th day of the experiment. Group IV (protected group) that received resveratrol in a dose of 25 mg/kg intraperitoneally for 21 days and cisplatin at 16th day of the experiment. Body and liver weight were estimated, biochemical measurements and histopathological study of the liver tissue were done.
Results: showed significant preservation of the liver function and histological structure.
Conclusion: it is concluded that resveratrol could protect liver against cisplatin side effects.
Keywords
Cisplatin; Liver toxicity; Resveratrol
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