Abdallah, R., Al-Sharaky, D., Taie, D., EL Masry, M., Samaka, R. (2021). The Prognostic Role of Β-Catenin Subcellular Localization in Hepatocellular Carcinoma of Egyptian Patients. The Egyptian Journal of Hospital Medicine, 82(1), 129-136. doi: 10.21608/ejhm.2021.139639
Rania Abdallah Abdallah; Dalia Refaat Al-Sharaky; Doha Maher Taie; Marwa Said EL Masry; Rehab Monir Samaka. "The Prognostic Role of Β-Catenin Subcellular Localization in Hepatocellular Carcinoma of Egyptian Patients". The Egyptian Journal of Hospital Medicine, 82, 1, 2021, 129-136. doi: 10.21608/ejhm.2021.139639
Abdallah, R., Al-Sharaky, D., Taie, D., EL Masry, M., Samaka, R. (2021). 'The Prognostic Role of Β-Catenin Subcellular Localization in Hepatocellular Carcinoma of Egyptian Patients', The Egyptian Journal of Hospital Medicine, 82(1), pp. 129-136. doi: 10.21608/ejhm.2021.139639
Abdallah, R., Al-Sharaky, D., Taie, D., EL Masry, M., Samaka, R. The Prognostic Role of Β-Catenin Subcellular Localization in Hepatocellular Carcinoma of Egyptian Patients. The Egyptian Journal of Hospital Medicine, 2021; 82(1): 129-136. doi: 10.21608/ejhm.2021.139639
The Prognostic Role of Β-Catenin Subcellular Localization in Hepatocellular Carcinoma of Egyptian Patients
1Pathology Department, Faculty of Medicine, Menoufia University, Shebin El Kom, Menoufia Governorate,
2Pathology Department, National Liver Institute, Menoufia University, Shebin El Kom, Menoufia Governorate, Egypt
Abstract
Background: Hepatocellular carcinoma (HCC) is one of the most common cancers in Egypt with fatal outcome. The molecular pathogenesis of this type of cancer is so complex involving interaction of several signaling pathways. Among those is Wingless (WNT)/β-catenin signaling pathway, which is frequently activated in HCC. Objectives: To investigate the relationship of different localization patterns of β-catenin in relation to different histopathologic parameters in Egyptian HCC cases. Patients and methods: One hundred and twenty-one (121) HCC specimens were subjected for β-catenin evaluation by immunohistochemistry. Results: The studied HCC cases showed β-catenin membranous expression in 47/121 (38.8%) of cases, while nucleocytoplasmic localization was observed in 31/121 (25.6%). Most of HCC cases that showed single tumor mass presentation exhibited negative nucleocytoplasmic expression pattern (79.2%, P=0.02). Membranous pool of β-catenin was associated with adverse prognostic factors like increased positivity among high-grade cases (P=0.04), higher H score value in cases having lymphovascular invasion, positive lymph node and higher (advanced) TMN stages (P = 0.01, 0.00, 0.00 &0.03 respectively). Conclusion: HCC cases showed heterogeneous β-catenin expression pattern. Membranous β-catenin localization was associated with aggressive prognostic parameters of HCC.
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