Soliman, A., Mahmoud, S., Dawood, R., Fayed, A., Fathey, A. (2021). Prophylactic Use of Tranexamic Acid in Reducing Blood Loss during Elective Cesarean Section. The Egyptian Journal of Hospital Medicine, 82(1), 6-10. doi: 10.12816/ejhm.2021.137140
Ayman A. Soliman; Sayed A. Mahmoud; Ragab M. Dawood; Aliaa A. Fayed; Amira A. Fathey. "Prophylactic Use of Tranexamic Acid in Reducing Blood Loss during Elective Cesarean Section". The Egyptian Journal of Hospital Medicine, 82, 1, 2021, 6-10. doi: 10.12816/ejhm.2021.137140
Soliman, A., Mahmoud, S., Dawood, R., Fayed, A., Fathey, A. (2021). 'Prophylactic Use of Tranexamic Acid in Reducing Blood Loss during Elective Cesarean Section', The Egyptian Journal of Hospital Medicine, 82(1), pp. 6-10. doi: 10.12816/ejhm.2021.137140
Soliman, A., Mahmoud, S., Dawood, R., Fayed, A., Fathey, A. Prophylactic Use of Tranexamic Acid in Reducing Blood Loss during Elective Cesarean Section. The Egyptian Journal of Hospital Medicine, 2021; 82(1): 6-10. doi: 10.12816/ejhm.2021.137140
Prophylactic Use of Tranexamic Acid in Reducing Blood Loss during Elective Cesarean Section
Department of Obstetrics and Gynecology, Faculty of Medicine, Menoufia University, Menoufia, Egypt
Abstract
Background: Primary postpartum hemorrhage (PPH) plays a major role in maternal mortality and morbidity like severe anemia, blood transfusion requirement, hospital stay and infection. Tranexamic acid is now recommended in treatment of PPH, yet its prophylactic use before delivery is still not recommended. Objective: To assess the efficacy of preoperative administration of Tranexamic acid in decreasing blood loss during elective cesarean section. Patients and Methods: The study was conducted at Department of Obstetrics and Gynecology of Menoufia University Hospitals. It included 100 pregnant females who went through elective cesarean section with age >18 and < 35 years and singleton alive fetus. They were randomly allocated to two groups: the study group of which women received 1 gm of tranexamic acid 20 minutes before skin incision and the control group who did not receive tranexamic acid. The assessment included the following: measurement of blood loss amount and estimation of postoperative 1st day hemoglobin and hematocrit value. Results: There was highly statistically significant difference between both groups regarding the amount of blood loss during cesarean delivery and blood loss 2 hours from end of CS (p ≤ 0.001). This was reflected in the percentage of difference of preoperative and postoperative hemoglobin and hematocrit values, which showed highly significant statistical difference (p ≤ 0.001). Conclusion: Tranexamic acid administration before elective cesarean section was effective in decreasing intraoperative and postoperative bleeding. And in turn reduces the incidence of PPH with no immediate maternal or neonatal side effects.
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