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Andrawes, N., Ismail, E., Roshdy, M., Ibrahim, A. (2017). Evaluation of Serum Angiopoietin-2 in Children and Adolescents with Sickle Cell Disease. The Egyptian Journal of Hospital Medicine, 68(1), 899-903. doi: 10.12816/0038189
Nevine G. Andrawes; Eman A. Ismail; Maged Maher Salib Roshdy; Amna Mohamed Ibrahim. "Evaluation of Serum Angiopoietin-2 in Children and Adolescents with Sickle Cell Disease". The Egyptian Journal of Hospital Medicine, 68, 1, 2017, 899-903. doi: 10.12816/0038189
Andrawes, N., Ismail, E., Roshdy, M., Ibrahim, A. (2017). 'Evaluation of Serum Angiopoietin-2 in Children and Adolescents with Sickle Cell Disease', The Egyptian Journal of Hospital Medicine, 68(1), pp. 899-903. doi: 10.12816/0038189
Andrawes, N., Ismail, E., Roshdy, M., Ibrahim, A. Evaluation of Serum Angiopoietin-2 in Children and Adolescents with Sickle Cell Disease. The Egyptian Journal of Hospital Medicine, 2017; 68(1): 899-903. doi: 10.12816/0038189

Evaluation of Serum Angiopoietin-2 in Children and Adolescents with Sickle Cell Disease

Article 12, Volume 68, Issue 1, July 2017, Page 899-903  XML PDF (540.47 K)
Document Type: Original Article
DOI: 10.12816/0038189
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Authors
Nevine G. Andrawes1; Eman A. Ismail2; Maged Maher Salib Roshdy3; Amna Mohamed Ibrahim1
1Pediatrics department , Faculty of Medicine, Ain Shams University
2Clinical PathologyDepartments, Faculty of Medicine, Ain Shams University
3Opthalmology Departments, Faculty of Medicine, Ain Shams University
Abstract
Background: A pro-angiogenic state has been found in adults with sickle cell disease (SCD), mainly because of elevated angiopoietin-2 levels. Aim of the work was to determine the level of Angiopoietin-2 in children and adolecents with SCD and assess its relation to markers of hemolysis and iron overload. Methods: Forty SCD patients in steady state were studied focusing on hydroxyurea therapy, hematological profile and serum ferritin. Patients were compared to 40 healthy controls.
Results: Angiopoietin-2 levels were significantly higher in SCD patients compared with healthy controls (8506.3 ± 3789.5 pg/mL versus 2791.7 ± 1263.6 pg/mL; p<0.001). Angiopoietin-2 levels were significantly higher in SCD patients with cardiopulmonary complications. Significant positive correlations were found between serum angiopoietin-2 levels and age as well as HbS. Conclusions: Elevated angiopietin-2 levels in SCD highlights the role of angiogenesis in the pathophysiology of SCD. Angiopoietin-2 may be considered a promising risk marker for screening of SCD patients at risk of cardiopulmonary complications.
 
Keywords
Serum Angiopoietin-2; children; Adolescents; Sickle Cell
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