A Randomized-Trial Study of Corneal Collagen Cross-Linking (CXL) in Progressive-Keratoconus (PK)

Document Type : Original Article

Author

Department of Ophthalmology, Faculty of Medicine, Al-Azhar University, Assiut, Egypt

Abstract

Background: Keratoconus is a frequent, familiar, bilateral, non inflammatory, and gradually progressive corneal ectasia, which leads to corneal protrusion, irregular astigmatism, and decrease vision. Currently, the corneal cross-linking (CXL) treatment could attain vision improvement.
Aim: To investigate the topographic, refractive, and clinical-out-comes after six months CXL in gradually progressing keratoconic eyes.
Patients & Methods: A follow-up, randomized, controlled-trial study was used. In this study, 30eyes with progressive- keratoconus (PK) were recruited in the study. Cross-linking was done and achieved by a solution of 0.1% riboflavin mixture with 20% dextran for 15minutes before and during 30minutes time-period of ultraviolet A (UV-A) irradiation (3Mw\cm2). The obtained data were analysed using IBM SPSS software.
Results: Statistically significant improvements were noticed in Sim k (at 6months), Kmin (at 6months), spherical power (at 6momths), cylinder power (at 6momths), spherical equivalent [SE] (at 6months), uncorrected visual acuity (UCVA) (at 6months) and best corrected visual acuity [BCVA] (at 6months) in trial group (15patients) when compared with the controls.
Conclusions: At 6months, hopeful, promising improvements were reported in Kmax, UCVA, and BCVA. So, long term studies are requested to survey the efficiency of CXL as well as the safety of the repeated procedures.

Keywords

The Egyptian Journal of Hospital Medicine
Volume 81, Issue 6
October 2020
Pages 2179-2183

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