Alsofyani, A., Alharbi, A., Alanazi, A., Alasous, K., Ageeli, R., ALZahrani, A., Almofarreh, M., Albalwi, R., Majrshi, S., Alsahli, M., Shaban, A., Ahmad, G. (2017). Correlation between Vitamin D Deficiency and Depression. The Egyptian Journal of Hospital Medicine, 69(8), 3134-3143. doi: 10.12816/0042865
Afnan Hedian Alsofyani; Abeer Mohammed M Alharbi; Arwa Bader N Alanazi; Khaled Abdul Aziz Alasous; Rawan Ahmad Ageeli; Amirah Abduallah M ALZahrani; Moatez Khalaf Almofarreh; Reham Awdah Albalwi; Samirah Nasser A Majrshi; Muhannad Fahad W Alsahli; Ayat Essam Shaban; Ghaida Mohammad Ahmad. "Correlation between Vitamin D Deficiency and Depression". The Egyptian Journal of Hospital Medicine, 69, 8, 2017, 3134-3143. doi: 10.12816/0042865
Alsofyani, A., Alharbi, A., Alanazi, A., Alasous, K., Ageeli, R., ALZahrani, A., Almofarreh, M., Albalwi, R., Majrshi, S., Alsahli, M., Shaban, A., Ahmad, G. (2017). 'Correlation between Vitamin D Deficiency and Depression', The Egyptian Journal of Hospital Medicine, 69(8), pp. 3134-3143. doi: 10.12816/0042865
Alsofyani, A., Alharbi, A., Alanazi, A., Alasous, K., Ageeli, R., ALZahrani, A., Almofarreh, M., Albalwi, R., Majrshi, S., Alsahli, M., Shaban, A., Ahmad, G. Correlation between Vitamin D Deficiency and Depression. The Egyptian Journal of Hospital Medicine, 2017; 69(8): 3134-3143. doi: 10.12816/0042865
Correlation between Vitamin D Deficiency and Depression
10Al Imam Abdulrahman Al Faisal Hospital in Riyadh
11Al Nahda Primary Health Care Center, Jeddah
12East Jeddah Hospital
Abstract
Aim of the Study: To conduct a systematic review and meta-analysis of prospective cohort studies of the association of vitamin D deficiency with onset of depression in non- depressed individuals. Methods: A systematic review of the electronically searched publications of the scientific literature. We searched the Cochrane Hepato Biliary Group Controlled Trials Register, Cochrane Central Register of Controlled Trials in The Cochrane Library, MEDLINE (1946 to 2017), EMBASE (1974 to 2017), and Science Citation Index Expanded (1900 to 2017). Initially all randomized clinical trials which studied the correlation of Vitamin D with depression were included, articles were then selectively screened according to the eligibility criteria. Results: the search yielded 11 studies, A meta-analysis of all studies without flaws demonstrated a statistically significant improvement in depression with Vitamin D supplements (+0.72 CI +0.28, +1.31). Nevertheless, studies with biological flaws were mainly inconclusive Conclusion: Our analyses are consistent with the hypothesis that Vitamin D supplementation (≥800 I.U. daily) was supported in the management of depression.
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