Review on Liver Cirrhosis Complications and Treatment

Alaqaili, Haider Issa; AlJuraysan, Ahmed Ibrahim; Hawsawi, Razan Mansour A; Abuzaid, Fadia Abdulelah; Alharbi, Muath Abdullah; Mughallis, Abdulrhman Ebrahim A.; Alsubhi, Yazeed Abdullah H; Asiri, Mohammed Rraiy A; Alamer, Abdullah Saleh S; Azab, Abdullah Mohammed S; Khaleel, Abdullah Javed; Al-Rajeh, Hanan Khalil Ibrahim

doi:10.12816/0042860

Review on Liver Cirrhosis Complications and Treatment

Document Type : Original Article

Authors

¹ Dammam Medical Complex

² King Faisal University

³ King sau-Hs

⁴ King Abdulaziz University,Medicine-Basic Medical Sciences-Anatomy,Research Assistant King Fahad Medical Research Center

⁵ Medical University of Lodz

⁶ Jazan General Hospital

⁷ King Abdulaziz University

⁸ Sharg Almjaredah PHCC

⁹ Qassim University

¹⁰ King Fahad Hospital

10.12816/0042860

Abstract

Background: cirrhosis is a late stage of scarring (fibrosis) of the liver caused by many forms of liver diseases and conditions, such as hepatitis and chronic alcoholism. The liver carries out several necessary functions, including detoxifying harmful substances in your body, cleaning your blood and making vital nutrients. Cirrhosis occurs in response to damage to your liver. Each time your liver is injured, it tries to repair itself. In the process, scar tissue forms. As cirrhosis progresses, more and more scar tissue forms, making it difficult for the liver to function.
Objective of the Study: review and evaluate the best practices in diagnosis, complications and management of cirrhosis, and novel clinical and scientific developments.
Methods: electronic search in the scientific database from 1966 to 2017– (Medline, Embase, the Cochrane Library as well as NHS center websites were searched for English Publications obtained from both reprint requests and by searching the database. Data extracted included authors, country, year of publication, age and sex of patients, epidemiology, geographical distribution, pathophysiology, risk factors, clinical manifestations, investigations and types of surgical treatment.
Results: there is sufficient body of evidence suggesting that cirrhosis is a pathological diagnosis with no laboratory cutoff values for the diagnosis of cirrhosis.
However, it can still be diagnosed clinically, by history, physical examination laboratory analyses and ancillary testing such as ultrasonography. Early diagnosis has proven to give relevantly better case management results while late detection can only hardly manage the symptoms accompanied with cirrhosis.
Conclusion: Screening for chronic liver disease is a key factor for early detection of signs for liver damage, which can be performed inexpensively and easily with clinical history-taking, measurement of transaminase concentrations, upper abdominal ultrasonography, and transient elastography (where available). Abnormal findings should prompt specific diagnostic testing to determine the etiology of the underlying disease. In most patients, the dynamic process of progressive fibrosis, which could ultimately lead to cirrhosis, can be interrupted by the timely recognition of the risk, followed by appropriate treatment.

Keywords