Natural History and Surgical Management of Oral Malignant Melanoma

Al Salman, Rahmah Hameed; Fageha, Mohammed Essam; Alghamdi, Khalid Abdulrahman S; Shamlan, Suzan Sulaiman Hamad; Almalki, Alaa Omar  D; Bardisi, Wajdi Mohammed; Albaradi, Khaled Hamad M; Alsharif, Majid Gais Faisal; Talab, Yara Tareq Mohammed

doi:10.12816/0042849

Natural History and Surgical Management of Oral Malignant Melanoma

Document Type : Original Article

Authors

¹ Alfarabi College

² Al-Farabi College for Nursing and Dentistry

³ ordan university of Science and technology

⁴ 5th years general dentist on batterjee medical college

⁵ umm al-qura university faculty of dentistry

⁶ Intern in KAU

⁷ Batterjee medical college

10.12816/0042849

Abstract

Pigmented entities are relatively common in the oral mucosa and arise from intrinsic and extrinsic sources. Conditions such as melanotic macules, nevi, smoker's melanosis, amalgam and graphite tattoos, racial pigmentation, and vascular blood-related pigments occur with some frequency. Addison disease, Peutz-Jeghers syndrome, and Laugier-Hunziker syndrome also appear in perioral and oral locations as pigmented macules. Detailed knowledge of melanoma at the molecular level allows the development of new treatment alternatives and to design effective new drugs. Addison disease presents as adrenal cortical hypofunction along with splotchy or generalized bronzing of the mucosa and skin. Peutz-Jeghers syndrome has periorificial freckling along with hamartomatous intestinal polyps, and, as a differential diagnosis, Laugier-Hunziker syndrome presents with macular mucocutaneous hyperpigmentation and melanonychia with no known systemic disease association. We conducted this review using a comprehensive search of MEDLINE, PubMed, EMBASE, Cochrane Database of Systematic Reviews, and Cochrane Central Register of Controlled Trials from January 1, 1970, through February 28, 2017.

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