Effect of Artificial Sweets on Neurologic Disorders

Alahmed, Ali Malik; Shokri, Mohammad Ehsan M; Ayidh, Faris Ali Nasser; Alotaib, Amer Baraki; Alghamdi, Tarnim Muhsen; Alziyadi, Faisal Barrak H; Alluhaydan, Abdulsalam S.; Alshahrani, Abdulwahab Malawi S; Alsaud, Nora Faisal; Gasem, Osama Abdulaziz M; Mughallis, Abdulrhman Ebrahim A.; Hassan H, Albayyali,Tariq

doi:10.12816/0042565

Effect of Artificial Sweets on Neurologic Disorders

Document Type : Original Article

Authors

¹ University Of Dammam( Imam Abdulrahman Bin Faisal University),

² King Abdulaziz University Hospital

³ King Khalid University

⁴ King Abdullah Hospital-Bisha

⁵ King Abdulaziz Hospital

⁶ Klakh PHC,7- King Saud Medical City-Riyadh

⁷ King Saud Medical City-Riyadh

⁸ Alfaisal University

⁹ King Abdulaziz University

¹⁰ Jazan General Hospital

¹¹ Aljouf University

10.12816/0042565

Abstract

Background: Sugar- and artificially-sweetened beverage consumption have been connected to cardio metabolic hazard factors, which rise the danger of cerebrovascular illness and dementia.
Purpose: We studied whether sugar or artificially sweetened beverage intake was related with the prospective dangers of incident stroke or dementia. Materials and methods: We studied 361 members aged more than 45 years for incident stroke (mean age 61 [SD, 10] years; 163 men) and 185 participants aged >60 years for incident dementia (mean age 68 [SD, 7] years; 85 men). Beverage consumption was computed using a food-frequency questionnaire at cohort studies. We quantified latest consumption at investigation 7 and cumulative intake by averaging across examinations. Surveillance for incident events commenced at examination 7 and continued for 5 years. We observed 12 cases of incident stroke (10 ischemic) and 10 cases of incident dementia (8 consistent with Alzheimer’s disease). Results: After modifications for age, gender, education (for analysis of dementia), caloric consumption, diet feature, physical activity, and smoking, higher recent and higher cumulative consumption of artificially sweetened soft drinks were related with an increased risk of ischemic stroke, all-cause dementia, and Alzheimer’s disease dementia. When comparing day-to-day aggregate consumption to 0 per week (reference), the risk ratios were 2.87 (95% confidence interval, 1.24–6.89) for ischemic stroke and 2.91 (95% confidence interval, 1.15–6.99) for Alzheimer’s disease. Sugar-sweetened beverages were not associated with stroke or dementia. Conclusions: Artificially sweetened soft drink consumption was allied with a higher risk of stroke and dementia.

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