Poly Cystic Ovarian Syndrome and Vit D Correlation with Fertility: Review Article

Alzaidi, Marah Mohammed; Almir, Hassan Hamza A; Khormi, Afraa Qasim Ibrahim; Alltaleb, Yassmeen Mohammed; Al Muwais, Zahra Mohamed A; Alsaleh, Rehab Abdul Rahman; Alsaud, Nora Faisal; Alomar, Lama Mohammed; Shabkah, Reema Adnan; Khormi, Abdulrahman Hassan; Safi, Reyhana

doi:10.12816/0042239

Poly Cystic Ovarian Syndrome and Vit D Correlation with Fertility: Review Article

Document Type : Original Article

Authors

¹ Department of Obstetrics and Gynecology, Taif University, Taif

² Department of Obstetrics and Gynecology Imam Abdulrahman bin Faisal university, Dammam

³ Department of Obstetrics and Gynecology, Jazan University, Jazan

⁴ Department of Obstetrics and Gynecology, Alfaisal University, Riyadh

⁵ Department of Obstetrics and Gynecology, Imam Abdulrahman bin Faisal university, Dammam

⁶ Department of Obstetrics and Gynecology, Ibn Sina National College, Jeddah

⁷ Department of Obstetrics and Gynecology, Alfaisal University

⁸ Department of Obstetrics and Gynecology, Almaarefa College for Science and Technology, Riyadh

⁹ Department of Obstetrics and Gynecology,King Abdulaziz University, Jeddah

¹⁰ Department of Obstetrics and Gynecology,king Fahd Central Hospital, Jazan, Saudi Arabia

¹¹ Department of Obstetrics and Gynecology,Ibn Sina National College, Jeddah

10.12816/0042239

Abstract

Over the past few decades, vitamin D was proposed to be highly influential on female fertility and reproductive health. Its role was extensively studied and evaluated specifically in females with polycystic ovarian syndrome. Objectives: the aim of this research was to study the correlation between vitamin D and fertility in general, and in polycystic ovarian syndrome-associated infertility in particular. Methods: we searched Cochrane Library and PubMed for articles addressing the impact and role of vitamin D in fertility issues in females with polycystic ovary disease. Specifically-related topics were carefully reviewed and analyzed to summarize their conclusive results. Results and Discussion: Vitamin D was lower in females with PCOS and vitamin D administration had increased its level, improved metabolic disturbance and shortened inter-menstrual intervals in those patients. Patients with high vitamin D levels had a better success rate of in-vitro fertilization. However, it did not affect the time to pregnancy in PCOS women. Conclusion: Vitamin D is beneficial for improving metabolic as well as reproductive functions in women with PCOS. It is also essential for successful in-vitro fertilization, and it is probably protective against endometriosis. However, results from different studies are contradictory, and still there is no solid evidence that there is a cause-effect relationship between vitamin D and fertility.

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