Al-Nemer, O., Alshareef, H., Aljehani, A., Gashgari, A., Alqarni, B., Bin Jariyd, A., Alshammari, F., Serri, M., Alsamadani, R., Sayyal, R. (2017). A Review of the Pathogenesis of Pediatric Asthma and the Effect of Leukotriene Modifiers in Pediatric Asthma Management. The Egyptian Journal of Hospital Medicine, 69(5), 2378-2383. doi: 10.12816/0041680
Ola Abdullah Al-Nemer; Haneen Jameel Alshareef; Afnan Abdullah Aljehani; Abrar Mohammed noor Gashgari; Bayan Ali Alqarni; Abdullah Abdulaziz Bin Jariyd; Fahad Obaid Alshammari; Muayad Mahmood Anbar Serri; Raed Mohammad noor Alsamadani; Rayan Ibrahim Sayyal. "A Review of the Pathogenesis of Pediatric Asthma and the Effect of Leukotriene Modifiers in Pediatric Asthma Management". The Egyptian Journal of Hospital Medicine, 69, 5, 2017, 2378-2383. doi: 10.12816/0041680
Al-Nemer, O., Alshareef, H., Aljehani, A., Gashgari, A., Alqarni, B., Bin Jariyd, A., Alshammari, F., Serri, M., Alsamadani, R., Sayyal, R. (2017). 'A Review of the Pathogenesis of Pediatric Asthma and the Effect of Leukotriene Modifiers in Pediatric Asthma Management', The Egyptian Journal of Hospital Medicine, 69(5), pp. 2378-2383. doi: 10.12816/0041680
Al-Nemer, O., Alshareef, H., Aljehani, A., Gashgari, A., Alqarni, B., Bin Jariyd, A., Alshammari, F., Serri, M., Alsamadani, R., Sayyal, R. A Review of the Pathogenesis of Pediatric Asthma and the Effect of Leukotriene Modifiers in Pediatric Asthma Management. The Egyptian Journal of Hospital Medicine, 2017; 69(5): 2378-2383. doi: 10.12816/0041680
A Review of the Pathogenesis of Pediatric Asthma and the Effect of Leukotriene Modifiers in Pediatric Asthma Management
Background: Asthma is the most common chronic illness that affects children. It is described by chronic airway inflammation, remodeling of the airway wall, and airway hyper-responsiveness to non-specific spasms in response to stimuli causing a reversible airflow obstruction. Leukotrienes are one of the primary chemical mediators of inflammation in asthmatic airway, therefore leukotriene modifiers are an important class of drug for treating asthma. Methodology: We conducted this review using a comprehensive search of MEDLINE, PubMed, and EMBASE, January 1981, through February 2017. The following search terms were used: asthma pathophysiology, chemokines, leukotriene, leukotriene modifiers, Montelukast in asthma management Aim: our aim was to understand in depth the pathophysiology of pediatric asthma, and to study the effect of leukotriene modifiers in asthma management. Conclusion: For management of pediatric asthma, the leukotriene modifiers play a key role. New studies have shown that they could help in reducing dose and dependency on inhaled corticosteroid for maintenance, and decrease the need of systemic steroids in exacerbation. Leukotriene modifiers can have a positive impact on future asthma management and requires more studies to be done in this subject.
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