Comparison between Cabergoline and Coasting in Prevention of Ovarian Hyperstimulation Syndrome and their effect on Intracytoplasmic Sperm Injection Outcome

Document Type : Original Article

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Department of Obstetrics and Gynecology, Faculty of Medicine, Al Azhar University

Abstract

Aim of the work: ovarian hyperstimulation syndrome (OHSS) is an iatrogenic, serious and potentially fatal complication of ovarian stimulation, affecting1–14% of all IVF/ICSI cycles. This study aimed to compare cabergoline after hCG administration with delayed hCG administration (coasting) in high risk patients to prevent OHSS in ART cycles. Patients and methods: this prospective comparative randomized study included 100 patients at risk of OHSS performed in the Assisted Reproductive Technologies Center, Al-Azhar University and in Private IVF Centers during the period from November, 2015 to October, 2016. Results: comparison between the two groups showed no significant difference regarding age, BMI, presence of risk factors of OHSS, but there was a significant difference regarding FSH, LH  and the mean diameter of follicles on day of hCG administration. Conclusion: PCOS affects 5 to 10% of women of childbearing age and is the most common cause of anovulatory infertility in developed countries. Recommendations: further studies including large number of cases and for longer duration will further confirm the efficacy of cabergoline and coasting on prevention of OHSS.

Keywords

The Egyptian Journal of Hospital Medicine
Volume 73, Issue 1
October 2018
Pages 5753-5769

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