Meta-Analysis Study on Alcoholic Liver Cirrhosis

Alfarsi, Hussam Musallam; Binobaid, Abdullah Obaid; Alghamdi, Thamer Saeed; Albeladi, Fedaa Hussain; Alqudaihi, Hassan Talal Abdulaziz; Alabdrabalrasol, Eman Ahmed Hassan; Al Barashdi, Umaima Ibrahim Khalfan; AlSaghirat, Mohammed Ali Mohammed; Hassan, Hayfa Ahmed; Alsaqabi, Qusai Abdullah; Al-Rashidi, Ahmad Fahad Eid; Hakami, Fahad Yahya Ahmad

doi:10.12816/0043976

Meta-Analysis Study on Alcoholic Liver Cirrhosis

Document Type : Original Article

Authors

¹ King Abdulaziz University

² Alfaisal University

³ Arabia Gulf University

⁴ Imam Abdulrahman bin Faisal University

⁵ Maabaila HC, Muscat

⁶ Aljouf University

⁷ Al Adan Hospital, Internal Medicine Department, Kuwait

⁸ Sabia PHC

10.12816/0043976

Abstract

Background: Heavy alcohol consumption is an inevitable cause of alcoholic liver disease with a high chance to progress to Alcoholic Liver Cirrhosis. Alcohol could damage the function of body organs and could cause cancer. Liver damage due to excessive alcohol consumption is usually presented as fatty liver (build-up of fats in the liver), steatohepatitis, fibrosis, alcoholic cirrhosis, and hepatocellular carcinoma. When liver fibrosis progresses, it will ultimately end up as alcoholic cirrhosis.
Objective of the Study: This article was intended to explore and investigate the possible optimal diagnosis and management of Alcoholic liver cirrhosis.
Methods: We searched the medical literatures to retrieve studies for the review till 30 November 2017. Electronic search in the scientific database from 1965 to 2017– (Medline, Embase. The Cochrane Library websites were searched for English Publications (both reprint requests and by searching the database).
Data extracted included authors, country, year of publication, characteristics of patients, pathophysiology, risk factors, clinical manifestations, different diagnostic approaches and treatment modalities.
Conclusion: Absolute abstinence remains the foundation for any treatment of any acute or chronic Alcoholic Liver Disease. It’s also important to understand that no treatment will cure cirrhosis or repair scarring in the liver that has already occurred and the only resort would be liver transplantation which is also debatable provided the complications it carries along. Nevertheless, timely diagnosis of alcoholic cirrhosis in people with alcoholic liver disease is the cornerstone for evaluation of prognosis or choosing treatment strategies such as nutritional and medical support and lifestyle change.

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