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Alanazi, A., Al-Enezi, A., Alanazi, K., Alanazi, M., Alanazi, N. (2018). Systemic Review: Role of Tissue Plasminogen Activator for Acute Ischemic Stroke. The Egyptian Journal of Hospital Medicine, 70(7), 1121-1130. doi: 10.12816/0044536
Abdullah Musari Alanazi; Abdullah Munif Al-Enezi; Khalid Hashim Alanazi; Muteb Lafi Alanazi; Nasser Nidaa Alanazi. "Systemic Review: Role of Tissue Plasminogen Activator for Acute Ischemic Stroke". The Egyptian Journal of Hospital Medicine, 70, 7, 2018, 1121-1130. doi: 10.12816/0044536
Alanazi, A., Al-Enezi, A., Alanazi, K., Alanazi, M., Alanazi, N. (2018). 'Systemic Review: Role of Tissue Plasminogen Activator for Acute Ischemic Stroke', The Egyptian Journal of Hospital Medicine, 70(7), pp. 1121-1130. doi: 10.12816/0044536
Alanazi, A., Al-Enezi, A., Alanazi, K., Alanazi, M., Alanazi, N. Systemic Review: Role of Tissue Plasminogen Activator for Acute Ischemic Stroke. The Egyptian Journal of Hospital Medicine, 2018; 70(7): 1121-1130. doi: 10.12816/0044536

Systemic Review: Role of Tissue Plasminogen Activator for Acute Ischemic Stroke

Article 8, Volume 70, Issue 7, January 2018, Page 1121-1130  XML PDF (1018.6 K)
Document Type: Original Article
DOI: 10.12816/0044536
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Authors
Abdullah Musari Alanazi; Abdullah Munif Al-Enezi; Khalid Hashim Alanazi; Muteb Lafi Alanazi; Nasser Nidaa Alanazi
Northern Border University
Abstract
Background: Using recombinant tissue plasminogen activator (rt-PA) during the first 3 h up to 6 h of stroke was allowed to reduce the poor functional consequences of stroke.
Objectives: assess the effects of intravenous dosage of rt-PA during the first 6 h after on early and late outcomes of acute ischemic stroke (AIS).
Methods: all studies regarding the intravenous rt-PA given within 6 h of onset of acute ischemic stroke up to 2016 were searched the outcomes, and the mortality rates were evaluated at the final follow up.
Results: There was a significant increase in functional outcome by using IV-tPA significantly (p <0.01).
 A significant decrease was found in intracranial hemorrhage in the patients treated with IV-tPA. The mortality rates were significantly decreased at the end of the follow up period in patients treated with IV-tPA.
Conclusion: The study indicated that using intravenous rt-PA could increase the number of living patients favorable outcome, less disabilities and intracranial hemorrhage among acute ischemic stroke patients during the first 6 hours.
 
Keywords
Systemic review; tissue plasminogen activator; acute ischaemic stroke; mortality
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