Helal, E., Almutairi, A., Abdelaziz, M., Mohamed, A. (2020). Adverse Effects of Fast Green, Sodium Nitrate and Glycine on Some Physiological Parameters. The Egyptian Journal of Hospital Medicine, 80(3), 964-970. doi: 10.21608/ejhm.2020.104304
Eman G.E. Helal; Aisha Almutairi; Mohamed A. Abdelaziz; Asmaa A. H. Mohamed. "Adverse Effects of Fast Green, Sodium Nitrate and Glycine on Some Physiological Parameters". The Egyptian Journal of Hospital Medicine, 80, 3, 2020, 964-970. doi: 10.21608/ejhm.2020.104304
Helal, E., Almutairi, A., Abdelaziz, M., Mohamed, A. (2020). 'Adverse Effects of Fast Green, Sodium Nitrate and Glycine on Some Physiological Parameters', The Egyptian Journal of Hospital Medicine, 80(3), pp. 964-970. doi: 10.21608/ejhm.2020.104304
Helal, E., Almutairi, A., Abdelaziz, M., Mohamed, A. Adverse Effects of Fast Green, Sodium Nitrate and Glycine on Some Physiological Parameters. The Egyptian Journal of Hospital Medicine, 2020; 80(3): 964-970. doi: 10.21608/ejhm.2020.104304
Adverse Effects of Fast Green, Sodium Nitrate and Glycine on Some Physiological Parameters
1Department of Zoology, Faculty of Science (Girls), Al-Azhar University, Egypt
2Department of Pediatrics, College of Medicine, Qassim University, Saudi Arabia.
3Department of Physiology, Faculty of Medicine (Boys), Al-Azhar University, Egypt
Abstract
Background: Food additives are a substance added to food to enhance its flavor or appearance or to preserve it. They are widely used nowadays. Objectives: The aim of the current work was to determine the hazardous effects of sodium nitrate, fast green and glycine on some physiological parameters such as liver enzymes, lipid profile , hormonal assays …etc. Materials and methods: This study has been done on forty male albino rats. The Animals were divided into four groups: Group I (Control untreated group), Group II (fast green-treated group), Group III (glycine-treated group) and Group IV (sodium nitrate-treated group). Estimation of some biochemical parameters (liver enzymes, kidney function tests, glucose, protein profile and lipid profile) and hormonal assays [testosterone, T3 (triiodothyronine), T4 (thyroxine) and insulin were done. Results: Body weight showed highly significant decreased in both sodium nitrate and fast green . There was an increase in the activities of AST and ALT as well as urea and creatinine, in both sodium nitrate and fast green groups. There was a decrease in plasma proteins in both fast green and sodium nitrate groups. Lipid profile [total cholesterol (TC), triglycerides (TG), very low-density lipoprotein-cholesterol (VLDL-chol) and low-density lipoprotein-cholesterol (LDL-chol)] were decreased in fast green-treated groups while high-density lipoprotein-cholesterol (HDL-chol) was increased. In sodium nitrate group, the lipid profile (TC, TG, VLDL and LDL) were increased while HDL was decreased. Serum glucose, insulin, and HOMA-IR (insulin resistance) were decreased in fast green-treated group and increased in sodium nitrate-treated group. There was a increase in T3 and T4 in fast green-treated group while were decreased in sodium nitrate-treated group. Testosterone decreased in fast green-, glycine- and sodium nitrate-treated groups. While glycine-treated group showed the same results as the control group. Conclusion: It could be concluded that minimizing the use of food additives protects young children and mature people from their destructive effects.
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