Amer, O., Naguib, M., Allam, A., Fouad, E. (2020). Evaluation of Serum Eosinophil-Derived Neurotoxin Level in Children with Bronchial Asthma and its Relation to Disease Severity. The Egyptian Journal of Hospital Medicine, 80(3), 951-957. doi: 10.21608/ejhm.2020.104301
Osama Taha Amer; Mohammed Sanad Naguib; Ayman Abdulrahman Allam; Essam Monir Ibraheem Fouad. "Evaluation of Serum Eosinophil-Derived Neurotoxin Level in Children with Bronchial Asthma and its Relation to Disease Severity". The Egyptian Journal of Hospital Medicine, 80, 3, 2020, 951-957. doi: 10.21608/ejhm.2020.104301
Amer, O., Naguib, M., Allam, A., Fouad, E. (2020). 'Evaluation of Serum Eosinophil-Derived Neurotoxin Level in Children with Bronchial Asthma and its Relation to Disease Severity', The Egyptian Journal of Hospital Medicine, 80(3), pp. 951-957. doi: 10.21608/ejhm.2020.104301
Amer, O., Naguib, M., Allam, A., Fouad, E. Evaluation of Serum Eosinophil-Derived Neurotoxin Level in Children with Bronchial Asthma and its Relation to Disease Severity. The Egyptian Journal of Hospital Medicine, 2020; 80(3): 951-957. doi: 10.21608/ejhm.2020.104301
Evaluation of Serum Eosinophil-Derived Neurotoxin Level in Children with Bronchial Asthma and its Relation to Disease Severity
Background: Asthma is a chronic inflammatory disease of multifactorial etiologies. The eosinophil is a major player in allergic disease. Therefore, direct measurement of eosinophilic inflammation is needed for diagnosis. Objective: To assess Eosinophil-Derived Neurotoxin serum level in children with bronchial asthma. Also, to determine the relation of these levels to severity of bronchial asthma in children. Patients and methods: This case control prospective study was conducted during the period from August 2018 to August 2019. This study included 85 cases (17 in each group) divided into: control, intermittent, mild, moderate and severe persistent asthma groups. This study was carried out at Pediatric Department of Zagazig University Hospitals. Results: Eosinophil-Derived Neurotoxin (EDN) concentrations were significantly increased in asthmatic children when compared to controls (p-value < 0.05). The current work revealed that EDN levels can be considered as a possible biomarker for asthma diagnosis (PPV = 91.9%, NPV = 100%, sensitivity = 100%, specificity = 64.7%). The level of serum EDN was statistically higher in moderate and severe 0.832. Conclusion: EDN level was higher in asthmatic children than controls and correlated with asthma severity. Therefore, serum EDN can be considered as a possible biomarker for diagnosis, grading of asthma severity and the degree of airway inflammation. Serum EDN had a significant correlation with mean spirometric parameters in asthmatics. Therefore, it can reflect airway resistance in asthmatic children.
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