Elsayed, Z., Elkady, M., Biomy, W., Ezz El Din, M., Ahmed, L., El-khazragy, N. (2018). Correlation between T Stage of the Tumor and Tumor Behavior in Locally Advanced Head and Neck Squamous Cell Carcinoma. The Egyptian Journal of Hospital Medicine, 72(8), 5001-5004. doi: 10.21608/ejhm.2018.10277
Zeinab Mohammed Abdel-Hafeez Elsayed; Mohammad Sabry Elkady; Waleed Abd Elmmonem Biomy; Mai Mohamed Ali Ezz El Din; Lamiaa Moustafa Abdel Megied Mohamed Ahmed; Nashwa El-khazragy. "Correlation between T Stage of the Tumor and Tumor Behavior in Locally Advanced Head and Neck Squamous Cell Carcinoma". The Egyptian Journal of Hospital Medicine, 72, 8, 2018, 5001-5004. doi: 10.21608/ejhm.2018.10277
Elsayed, Z., Elkady, M., Biomy, W., Ezz El Din, M., Ahmed, L., El-khazragy, N. (2018). 'Correlation between T Stage of the Tumor and Tumor Behavior in Locally Advanced Head and Neck Squamous Cell Carcinoma', The Egyptian Journal of Hospital Medicine, 72(8), pp. 5001-5004. doi: 10.21608/ejhm.2018.10277
Elsayed, Z., Elkady, M., Biomy, W., Ezz El Din, M., Ahmed, L., El-khazragy, N. Correlation between T Stage of the Tumor and Tumor Behavior in Locally Advanced Head and Neck Squamous Cell Carcinoma. The Egyptian Journal of Hospital Medicine, 2018; 72(8): 5001-5004. doi: 10.21608/ejhm.2018.10277
Correlation between T Stage of the Tumor and Tumor Behavior in Locally Advanced Head and Neck Squamous Cell Carcinoma
1Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Ain Shams University
2Department of Clinical Pathology Faculty of Medicine, Ain Shams University
Abstract
Background: Head and neck cancer (HNC) represents more than 550,000 cases annually. It accounts for 380,000 deaths every year. Despite aggressive treatment, only 35% to 55% of patients who present with locally advanced HNC remain alive and free of disease 3 years after standard curative treatment. Thirty percent to 40% of patients develop locoregional recurrences, and distant metastases occur in 20% to 30%. Most recurrences appear quickly within 2 years of initial treatment and an additional 10% of patients will have evidence of distant metastases at the time of first presentation. Purpose: To retrospectively determine the prognostic effect of T stage in locally advanced head and neck cancer. Patients and Methods: This study retrospectively analyzed 40 patients diagnosed with locally advanced head and neck cancer. Patients were diagnosed by a tissue biopsy and they were staged by endoscope and CT neck or MRI neck with contrast. They received their treatment and were followed up every 3 months by CTs. Results: We found a statistically significant correlation between T stage and both PFS and OS in HNC (95%, CI 1.00 – 3.10, p=0.04 and 95% CI 1.01 – 2.65, p=0.05 respectively). We did not find any other statistically significant correlation between other patients’ sub-groups such as age, gender, smoking, affected site, stage, lymph node infiltration, receiving induction chemotherapy, receiving radiotherapy with or without chemotherapy, and response to treatment and between PFS and OS. Conclusion: This study confirmed that the T stage of the tumor is an important prognostic factor in locally advanced head and neck cancer.
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